The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF). Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter S phase, grow in semisolid medium, and become morphologically transformed. These mitogenic effects are absolutely depende...

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Veröffentlicht in:	Cell 1991-07, Vol.66 (1), p.173-183
Hauptverfasser:	Cordon-Cardo, Carlos, Tapley, Peter, Jing, Shuqian, Nanduri, Venkata, O'Rourke, Edward, Lamballe, Fabienne, Kovary, Karla, Klein, Rüdiger, Jones, Kevin R., Reichardt, Louis F., Barbacid, Mariano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain-Derived Neurotrophic Factor Cell Cycle - drug effects Cell Division - drug effects Cell Line Cell physiology DNA Replication - drug effects Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology Phosphorylation Plasmids Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-fos Proto-Oncogenes Receptor, trkA Receptors, Cell Surface - metabolism Receptors, Nerve Growth Factor Responses to growth factors, tumor promotors, other factors Transfection
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