Pygo2 Expands Mammary Progenitor Cells by Facilitating Histone H3 K4 Methylation

Recent studies have unequivocally identified multipotent stem/progenitor cells in mammary glands, offering a tractable model system to unravel genetic and epigenetic regulation of epithelial stem/progenitor cell development and homeostasis. In this study, we show that Pygo2, a member of an evolution...

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Veröffentlicht in:	The Journal of cell biology 2009-06, Vol.185 (5), p.811-826
Hauptverfasser:	Gu, Bingnan, Sun, Peng, Yuan, Yuanyang, Moraes, Ricardo C., Li, Aihua, Teng, Andy, Agrawal, Anshu, Rhéaume, Catherine, Bilanchone, Virginia, Veltmaat, Jacqueline M., Takemaru, Ken-Ichi, Millar, Sarah, Lee, Eva Y.-H. P., Lewis, Michael T., Li, Boan, Dai, Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Breasts Cell Cycle Cell Proliferation Cells Chromatin Epithelial cells Gene Expression Regulation Genes Genetics Histone-Lysine N-Methyltransferase Histones Histones - metabolism Humans Intracellular Signaling Peptides and Proteins - metabolism Intracellular Signaling Peptides and Proteins - physiology Lysine - metabolism Mammary glands Mammary Glands, Animal - cytology Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mesenchymal stem cells Methylation Mice Multipotent stem cells Phenotype Progenitor cells Rodents Small interfering RNA Stem cells Stem Cells - metabolism Wnt Proteins - genetics Wnt Proteins - metabolism
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