recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense. We show that FcRn traffics IgG from either apical or basolateral membranes into the recycling endosome (RE), after which the actin motor...

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Veröffentlicht in:	The Journal of cell biology 2009-05, Vol.185 (4), p.673-684
Hauptverfasser:	Tzaban, Salit, Massol, Ramiro H, Yen, Elizabeth, Hamman, Wendy, Frank, Scott R, Lapierre, Lynne A, Hansen, Steen H, Goldenring, James R, Blumberg, Richard S, Lencer, Wayne I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Compartmentation Cell Line Cell lines Cell Membrane - metabolism Cell membranes Cell Polarity Cells Dogs Endosomes Endosomes - metabolism Endothelial cells Epithelial cells Humans Immunoglobulin G - metabolism Immunoglobulins Kidney cells Membranes Myosin Heavy Chains - physiology Myosin Type V - physiology P branes Protein Transport Proteins rab GTP-Binding Proteins - physiology Receptors Receptors, Fc - metabolism Recycling Transcytosis
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