Single-Channel Current Through Nicotinic Receptor Produced by Closure of Binding Site C-Loop

We investigated the initial coupling of agonist binding to channel gating of the nicotinic acetylcholine receptor using targeted molecular-dynamics (TMD) simulation. After TMD simulation to accelerate closure of the C-loops at the agonist binding sites, the region of the pore that passes through the...

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Veröffentlicht in:	Biophysical journal 2009-05, Vol.96 (9), p.3582-3590
Hauptverfasser:	Wang, Hai-Long, Toghraee, Reza, Papke, David, Cheng, Xiao-Lin, McCammon, J. Andrew, Ravaioli, Umberto, Sine, Steven M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACETYLCHOLINE Animals Binding Sites BIOLOGY Biophysical Theory and Modeling Calcium - metabolism CATIONS Cell Line CELL MEMBRANES Chlorides - metabolism CLOSURES Computer Simulation Electric Conductivity FUNCTIONALS Humans Magnesium - metabolism Membrane Potentials - physiology Models, Molecular Molecules Monte Carlo Method Monte Carlo simulation Nicotinic Agonists - metabolism Potassium - metabolism Protein Conformation Receptors, Nicotinic - chemistry Receptors, Nicotinic - metabolism SIMULATION Sodium - metabolism STRUCTURAL MODELS Thermodynamics Torpedo TRANSLOCATION TRANSPORT Water - metabolism
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