Redistribution of Terbium Ions Across Acetylcholine Receptor-Enriched Membranes Induced by Agonist Desensitization

Using small-angle x-ray diffraction from centrifugally oriented acetylcholine receptor (AChR) enriched membranes coupled with anomalous scattering from terbium ions (Tb 3+) titrated into presumed Ca 2+ binding sites, we have mapped the distribution of Tb 3+ perpendicular to the membrane plane using...

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Veröffentlicht in:	Biophysical journal 2009-04, Vol.96 (7), p.2637-2647
Hauptverfasser:	Lee, Thomas E., Chuang, Anthony R., Marek, Matthew S., Doniach, Sebastian, Fairclough, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Calcium Carbachol - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Channels, Receptors, and Electrical Signaling Chemical elements Cholinergic Agonists - pharmacology Diffraction Ion Channel Gating - drug effects Ion Channels - chemistry Ion Channels - metabolism Ions Membranes Phase Transition Porosity Protein Stability Protein Structure, Tertiary Receptors, Cholinergic - chemistry Receptors, Cholinergic - metabolism Scattering, Small Angle Terbium - metabolism Terbium - pharmacology Titrimetry Torpedo X-Ray Diffraction
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