RNA interference targeting the platelet-derived growth factor receptor β subunit ameliorates experimental hepatic fibrosis in rats

Background/Aims: Platelet‐derived growth factor (PDGF) is the strongest stimulator of the proliferation of hepatic stellate cells (HSCs). PDGF receptor β subunit (PDGFR‐β) is acquired on HSCs proliferation induced by PDGF. In this study, we aim to investigate the effect of PDGFR‐β small interference...

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Veröffentlicht in:	Liver international 2008-11, Vol.28 (10), p.1446-1457
Hauptverfasser:	Chen, Si-Wen, Zhang, Xing-Rong, Wang, Chong-Ze, Chen, Wei-Zhong, Xie, Wei-Fen, Chen, Yue-Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Studies Blotting, Western Bromodeoxyuridine Cell Line Cell Proliferation DNA Primers - genetics Fluorescent Antibody Technique Gene Expression Regulation - genetics gene therapy Genetic Therapy - methods hepatic fibrosis hepatic stellate cells Hepatic Stellate Cells - metabolism Liver Cirrhosis, Experimental - genetics Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - therapy platelet-derived growth factor receptor β subunit (PDGFR-β) Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta - genetics Receptor, Platelet-Derived Growth Factor beta - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Small Interfering - genetics Transfection - methods
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