Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum

To evaluate the effect of rosiglitazone in a murine model of liver fibrosis induced by Schistosoma japonicum infection. A total of 50 mice were randomly and averagely divided into groups A, B, C, D and E. The mice in group A served as normal controls, while those in the other four groups were infect...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2008-05, Vol.14 (18), p.2905-2911
Hauptverfasser:	Chen, Hui, He, Yong-Wen, Liu, Wen-Qi, Zhang, Jing-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Anthelmintics - pharmacology Collagen Type I - metabolism Collagen Type III - metabolism Disease Models, Animal Hypoglycemic Agents - pharmacology Interleukin-6 - blood Liver - parasitology Liver - pathology Liver Cirrhosis - parasitology Liver Cirrhosis - pathology Liver Cirrhosis - prevention & control Mice NF-kappa B - metabolism PPAR gamma - genetics PPAR gamma - metabolism Praziquantel - pharmacology Rapid Communication RNA, Messenger - metabolism Rosiglitazone Schistosoma japonicum Schistosomiasis japonica - complications Schistosomiasis japonica - drug therapy Thiazolidinediones - pharmacology Transforming Growth Factor beta1 - metabolism Tumor Necrosis Factor-alpha - blood
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