Photo-Affinity Isolation and Identification of Proteins in Cancer Cell Extracts that Bind to Platinum-Modified DNA

The activity of the anticancer drug cisplatin is a consequence of its ability to bind DNA. Platinum adducts bend and unwind DNA duplex, creating recognition sites for nuclear proteins. Following DNA damage recognition, the lesions will either be repaired, facilitating cell viability, or if repair is...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2009-01, Vol.10 (1), p.141-157
Hauptverfasser:	Guggenheim, Evan R., Xu, Dong, Zhang, Christiana X., Chang, Pamela V., Lippard, Stephen J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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