Selective Degeneration of Central Photoreceptors after Hyperbaric Oxygen in Normal and Metallothionein-Knockout Mice

Metallothioneins (MTs) in the brain and retina are believed to bind metals and reduce free radicals, thereby protecting neurons from oxidative damage. This study was undertaken to investigate whether retinal photoreceptor (PR) cells lacking MTs are more susceptible to hyperbaric oxygen (HBO)-induced...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2008-07, Vol.49 (7), p.3207-3215
Hauptverfasser:	Nachman-Clewner, Michele, Giblin, Frank J, Dorey, C. Kathleen, Blanks, Robert H. I, Dang, Loan, Dougherty, Christopher J, Blanks, Janet C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Death Cell Nucleus - pathology Cell Survival Disease Susceptibility Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Hyperbaric Oxygenation - adverse effects Medical sciences Metallothionein - deficiency Mice Mice, Knockout Ophthalmology Photoreceptor Cells - pathology Retinal Degeneration - etiology Retinal Degeneration - metabolism Retinal Degeneration - pathology Retinal Degeneration - physiopathology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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