Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

The DNA double-strand break (DSB) repair protein DNA-PKcs and the signal transducer ATM are both activated by DNA breaks and phosphorylate similar substrates in vitro, yet appear to have distinct functions in vivo. Here, we show that ATM and DNA-PKcs have overlapping functions in lymphocytes. Ablati...

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Veröffentlicht in:	Molecular cell 2009-05, Vol.34 (3), p.285-297
Hauptverfasser:	Callén, Elsa, Jankovic, Mila, Wong, Nancy, Zha, Shan, Chen, Hua-Tang, Difilippantonio, Simone, Di Virgilio, Michela, Heidkamp, Gordon, Alt, Frederick W., Nussenzweig, André, Nussenzweig, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Ataxia Telangiectasia Mutated Proteins Base Sequence Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured DNA DNA Breaks, Double-Stranded DNA Repair DNA-Activated Protein Kinase - genetics DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fibroblasts - cytology Fibroblasts - physiology Genomic Instability Immunoglobulin Class Switching Lymphocytes - cytology Lymphocytes - physiology Mice Mice, Knockout Molecular Sequence Data MOLIMMUNO Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism PROTEINS Repressor Proteins - genetics Repressor Proteins - metabolism Thymus Gland - cytology Tripartite Motif-Containing Protein 28 Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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