Amplification mechanisms for the enhancement of antigen-mediated mast cell activation

Activation of mast cells in the allergic inflammatory response occurs via the high affinity receptor for IgE (FcεRI) following receptor aggregation induced by antigen-mediated cross-linking of IgE-occupied FcεRI. Recent observations suggest this response is profoundly influenced by other factors tha...

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Veröffentlicht in:	Immunologic research 2009, Vol.43 (1-3), p.15-24
Hauptverfasser:	Gilfillan, Alasdair M., Peavy, Richard D., Metcalfe, Dean D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Allergology Animals Antigens Biomedical and Life Sciences Biomedicine Cell Degranulation - immunology Cells Cytokines Humans Immunology Internal Medicine Mast Cells - immunology Mast Cells - metabolism Medicine/Public Health Molecular biology Mutation Phosphatidylinositol 3-Kinases - immunology Phosphatidylinositol 3-Kinases - metabolism Receptors, G-Protein-Coupled - immunology Receptors, G-Protein-Coupled - metabolism Receptors, IgE - immunology Receptors, IgE - metabolism Signal Transduction - immunology Stem Cell Factor - immunology Stem Cell Factor - metabolism
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