FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells

Inhibitor of differentiation 2 (Id2) is a natural inhibitor of the basic helix-loop-helix transcription factors. Although Id2 is well known to prevent differentiation and promote cell-cycle progression and tumorigenesis, the molecular events that regulate Id2 activity remain to be investigated. Here...

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Veröffentlicht in:	Nucleic acids research 2009-07, Vol.37 (12), p.3996-4009
Hauptverfasser:	Han, Weidong, Wu, Zhiqiang, Zhao, Yali, Meng, Yuanguang, Si, Yiling, Yang, Jie, Fu, Xiaobing, Yu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Cell Differentiation Cell Line Cell Line, Tumor DNA - metabolism E-Box Elements Gene Expression Regulation, Neoplastic Helix-Loop-Helix Motifs Homeodomain Proteins - chemistry Homeodomain Proteins - metabolism Humans Inhibitor of Differentiation Protein 2 - antagonists & inhibitors Inhibitor of Differentiation Protein 2 - metabolism LIM-Homeodomain Proteins Molecular Biology Muscle Proteins - chemistry Muscle Proteins - metabolism Neuroblastoma - genetics Neuroblastoma - metabolism Repressor Proteins - metabolism TCF Transcription Factors - metabolism Transcription Factor 7-Like 1 Protein Transcription Factors - chemistry Transcription Factors - metabolism Two-Hybrid System Techniques Up-Regulation
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