Functional Roles of the Tetramer Organization of Malic Enzyme

Malic enzyme has a dimer of dimers quaternary structure in which the dimer interface associates more tightly than the tetramer interface. In addition, the enzyme has distinct active sites within each subunit. The mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) isoform behaves cooperativel...

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Veröffentlicht in:	The Journal of biological chemistry 2009-07, Vol.284 (27), p.18096-18105
Hauptverfasser:	Hsieh, Ju-Yi, Chen, Shao-Hung, Hung, Hui-Chih
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography Dimerization Enzyme Activation Enzyme Catalysis and Regulation Humans Hydrophobic and Hydrophilic Interactions Kinetics Malate Dehydrogenase - chemistry Malate Dehydrogenase - genetics Models, Chemical Molecular Weight Mutagenesis, Site-Directed Protein Structure, Quaternary Recombinant Proteins - chemistry Recombinant Proteins - genetics
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