Disruption of Large-Scale Brain Systems in Advanced Aging

Cognitive decline is commonly observed in advanced aging even in the absence of disease. Here we explore the possibility that normal aging is accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demon...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2007-12, Vol.56 (5), p.924-935
Hauptverfasser:	Andrews-Hanna, Jessica R., Snyder, Abraham Z., Vincent, Justin L., Lustig, Cindy, Head, Denise, Raichle, Marcus E., Buckner, Randy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Aging Aging - physiology Amyloid - metabolism Attention - physiology Brain Brain - growth & development Brain - physiology Cognition & reasoning Cognition - physiology Cognition Disorders - physiopathology Data Interpretation, Statistical Female Humans HUMDISEASE Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical imaging Memory Middle Aged Nerve Net - growth & development Nerve Net - physiology Neuropsychological Tests Older people Prefrontal Cortex - cytology Prefrontal Cortex - growth & development Prefrontal Cortex - physiology SYSNEURO Visual Cortex - physiology
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