Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

Transient receptor potential A1 (TRPA1) is expressed in a subset of nociceptive sensory neurons where it acts as a sensor for environmental irritants, including acrolein, and some pungent plant ingredients such as allyl isothiocyanate and cinnamaldehyde. These exogenous compounds activate TRPA1 by c...

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Veröffentlicht in:	The Journal of neuroscience 2008-03, Vol.28 (10), p.2485-2494
Hauptverfasser:	Andersson, David A, Gentry, Clive, Moss, Sian, Bevan, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - pharmacology Animals Cells, Cultured CHO Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Female Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Humans Male Mice Mice, Knockout Oxidative Stress - drug effects Oxidative Stress - physiology Rats Rats, Wistar Sensory Receptor Cells - physiology Transient Receptor Potential Channels - biosynthesis Transient Receptor Potential Channels - genetics Transient Receptor Potential Channels - metabolism TRPA1 Cation Channel
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