The Lateral Gate of SecYEG Opens during Protein Translocation

The SecYEG translocon of Escherichia coli mediates the translocation of preproteins across the cytoplasmic membrane. Here, we have examined the role of the proposed lateral gate of the translocon in translocation. A dual cysteine cross-linking approach allowed the introduction of cross-linker arms o...

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Veröffentlicht in:	The Journal of biological chemistry 2009-06, Vol.284 (23), p.15805-15814
Hauptverfasser:	du Plessis, David J.F., Berrelkamp, Greetje, Nouwen, Nico, Driessen, Arnold J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Cysteine - metabolism Cytoplasm - metabolism Disulfides - metabolism Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Euryarchaeota - genetics Euryarchaeota - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport, Structure, Function, and Biogenesis Models, Molecular Mutagenesis, Site-Directed Peptide Hydrolases - metabolism Porins - metabolism Protein Conformation Protein Precursors - genetics Protein Precursors - metabolism Protein Transport - genetics SEC Translocation Channels
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