GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage

A thorough examination of glucose-dependent insulinotropic polypeptide (GIP) expression has been hampered by difficulty in isolating widely dispersed, GIP-producing enteroendocrine K-cells. To elucidate the molecular mechanisms governing the regulation of GIP expression, 14 intestinal and pancreatic...

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Veröffentlicht in:	Molecular and cellular endocrinology 2008-06, Vol.287 (1), p.20-29
Hauptverfasser:	Jepeal, Lisa I., Boylan, Michael O., Michael Wolfe, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay Cell Line Cell Lineage Gastric Inhibitory Polypeptide - genetics Gastric Inhibitory Polypeptide - metabolism GATA-4 GATA4 Transcription Factor - antagonists & inhibitors GATA4 Transcription Factor - metabolism Gene expression GIP Glucose-dependent insulinotropic polypeptide Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Insulin Intestines - cytology Intestines - metabolism ISL-1 LIM-Homeodomain Proteins Luciferases - metabolism Mice Pancreas - cytology Pancreas - metabolism PDX-1 Promoter Regions, Genetic - genetics Rats RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors Up-Regulation - drug effects Up-Regulation - genetics
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