Microcephalin Regulates BRCA2 and Rad51-Associated DNA Double-Strand Break Repair

Microcephalin (MCPH1) is a BRCA1 COOH terminal (BRCT) domain containing protein involved in the cellular response to DNA damage that has been implicated in autosomal recessive primary microcephaly. MCPH1 is recruited to sites of DNA double-strand breaks by phosphorylated histone H2AX (gammaH2AX), bu...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-07, Vol.69 (13), p.5531-5536
Hauptverfasser:	XIANGLIN WU, MONDAL, Gourish, XIANSHU WANG, JIANMIN WU, LIN YANG, PANKRATZ, Vernon S, ROWLEY, Matthew, COUCH, Fergus J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis Regulatory Proteins Biological and medical sciences BRCA2 Protein - genetics BRCA2 Protein - metabolism BRCA2 Protein - radiation effects DNA Damage - radiation effects DNA Primers DNA Repair - genetics DNA Repair - radiation effects Glutathione Transferase - genetics Humans Medical sciences Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Nerve Tissue Proteins - radiation effects Pharmacology. Drug treatments Plasmids Rad51 Recombinase - genetics RNA, Small Interfering - genetics T-Lymphocytes - immunology T-Lymphocytes - radiation effects Tumors
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