DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation

DNA methylation is a major epigenetic factor regulating genome reprogramming, cell differentiation and developmental gene expression. To understand the role of DNA methylation in central nervous system (CNS) neurons, we generated conditional Dnmt1 mutant mice that possess ∼90% hypomethylated cortica...

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Veröffentlicht in:	Human molecular genetics 2009-08, Vol.18 (15), p.2875-2888
Hauptverfasser:	Hutnick, Leah K., Golshani, Peyman, Namihira, Masakasu, Xue, Zhigang, Matynia, Anna, Yang, X. William, Silva, Alcino J., Schweizer, Felix E., Fan, Guoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cerebral Cortex - embryology Cerebral Cortex - growth & development Cerebral Cortex - physiology DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Hippocampus - embryology Hippocampus - growth & development Hippocampus - physiology Mice Mice, Knockout Molecular and cellular biology Neurogenesis Neurons - physiology Prosencephalon - embryology Prosencephalon - growth & development Prosencephalon - physiology
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