Folding versus aggregation: Polypeptide conformations on competing pathways

Protein aggregation has now become recognised as an important and generic aspect of protein energy landscapes. Since the discovery that numerous human diseases are caused by protein aggregation, the biophysical characterisation of misfolded states and their aggregation mechanisms has received increa...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2008-01, Vol.469 (1), p.100-117
Hauptverfasser:	Jahn, Thomas R., Radford, Sheena E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Amyloid - chemistry Amyloid fibril formation Energy landscape Intermediate states Oligomers Protein Conformation Protein Folding Protein misfolding Review
Online-Zugang:	Volltext
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