Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study
Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear. We studied 1975 Framingham Offspring Study parti...
Gespeichert in:
| Veröffentlicht in: | Stroke (1970) 2009-05, Vol.40 (5), p.1590-1596 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1596 |
|---|---|
| container_issue | 5 |
| container_start_page | 1590 |
| container_title | Stroke (1970) |
| container_volume | 40 |
| creator | ROMERO, José R BEISER, Alexa SESHADRI, Sudha BENJAMIN, Emelia J POLAK, Joseph F VASAN, Ramachandran S AU, Rhoda DECARLI, Charles WOLF, Philip A |
| description | Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear.
We studied 1975 Framingham Offspring Study participants free of stroke and dementia with available carotid ultrasound, brain MRI, and neuropsychological testing. We related common and internal carotid artery intima-media thickness and internal carotid stenosis to large white matter hyperintensity (>1 SD above age-specific mean), total brain volume, hippocampal volume, silent cerebral infarcts, and neuropsychological measures of verbal memory, executive function, and nonverbal memory measures.
We observed that internal carotid artery intima-media thickness, but not common carotid artery intima-media thickness, was associated with higher prevalence of silent cerebral infarcts (OR, 1.21; 95% CI, 1.03-1.43; P |
| doi_str_mv | 10.1161/STROKEAHA.108.535245 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2705324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67176375</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-e33eab67fdc170f98b180adc64d18756fad51f44761bc6f6ff56612a8b981cb53</originalsourceid><addsrcrecordid>eNpVkU2P0zAQhi0EYsvCP0DIFzg1xd9JLkih2mUjFq20W87WxLEbo8QpdrpS_z2pWhU42CPNPPPOaF6E3lOyolTRz0-bx4fvN9VdtaKkWEkumZAv0ILOMROKFS_RghBeZkyU5RV6k9IvQgjjhXyNrmjJlCRSLFBaQxwn3-IqTjYecDV1No7J9MffpyX-8VjjOrTe2IRHh79G8AHXyXR28LDE1daH7RJDaPF63AY_-WeL62EHPg42THjTWXwbYZipDgb8NO3bw1v0ykGf7LtzvEY_b28267vs_uFbva7uMyOYmjLLuYVG5a41NCeuLBpaEGiNEi0tcqkctJI6IXJFG6Occk4qRRkUTVlQ00h-jb6cdHf7ZrCtmfeJ0Otd9APEgx7B6_8rwXd6Oz5rlhPJmZgFPp0F4vh7b9OkB5-M7XsIdtwnrXKaK54fJ4kTaOarpWjdZQgl-uiWvrg1Zwp9cmtu-_Dvgn-bzvbMwMczAMlA7yIE49OFY1QoOT_-B019n_k</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67176375</pqid></control><display><type>article</type><title>Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study</title><source>MEDLINE</source><source>American Heart Association</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>ROMERO, José R ; BEISER, Alexa ; SESHADRI, Sudha ; BENJAMIN, Emelia J ; POLAK, Joseph F ; VASAN, Ramachandran S ; AU, Rhoda ; DECARLI, Charles ; WOLF, Philip A</creator><creatorcontrib>ROMERO, José R ; BEISER, Alexa ; SESHADRI, Sudha ; BENJAMIN, Emelia J ; POLAK, Joseph F ; VASAN, Ramachandran S ; AU, Rhoda ; DECARLI, Charles ; WOLF, Philip A</creatorcontrib><description><![CDATA[Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear.
We studied 1975 Framingham Offspring Study participants free of stroke and dementia with available carotid ultrasound, brain MRI, and neuropsychological testing. We related common and internal carotid artery intima-media thickness and internal carotid stenosis to large white matter hyperintensity (>1 SD above age-specific mean), total brain volume, hippocampal volume, silent cerebral infarcts, and neuropsychological measures of verbal memory, executive function, and nonverbal memory measures.
We observed that internal carotid artery intima-media thickness, but not common carotid artery intima-media thickness, was associated with higher prevalence of silent cerebral infarcts (OR, 1.21; 95% CI, 1.03-1.43; P<0.05), large white matter hyperintensity (OR, 1.19; 95% CI, 1.03-1.38; P<0.05), lower total brain volume (-0.05 per SD; P<0.05), and poorer performance in verbal memory (-0.06 per SD; P<0.05) and nonverbal memory measures (-0.08 per SD; P<0.01), but not with hippocampal volume. Internal carotid stenosis >or=25% was associated with a higher prevalence of large white matter hyperintensity (adjusted OR, 1.77; 95% CI, 1.25-2.53) and lower total brain volume (-0.11 per SD; P=0.042) but not with silent cerebral infarcts or hippocampal volume. Internal carotid stenosis >or=50% was associated with higher prevalence of silent cerebral infarcts (OR, 2.53; 95% CI, 1.17-5.44), large white matter hyperintensity (OR, 2.35; 95% CI, 1.08-5.13), and poorer performance on executive function (-0.39 per SD; P<0.05), but not with total brain volume or hippocampal volume.
Carotid atherosclerosis markers were associated with MRI indices of brain ischemia and aging and with cognitive impairment in a community-based sample of middle-aged adults. Our data suggest that internal carotid artery intima-media thickness may be a better marker for cognitive impairment than common carotid artery intima-media thickness.]]></description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.108.535245</identifier><identifier>PMID: 19265054</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aging - physiology ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - complications ; Atherosclerosis - pathology ; Atherosclerosis - psychology ; Biological and medical sciences ; Blood and lymphatic vessels ; Brain - pathology ; Brain Ischemia - complications ; Brain Ischemia - pathology ; Brain Ischemia - psychology ; Cardiology. Vascular system ; Carotid Arteries - pathology ; Carotid Artery Diseases - complications ; Carotid Artery Diseases - pathology ; Carotid Artery Diseases - psychology ; Carotid Artery, Common - diagnostic imaging ; Carotid Artery, Common - pathology ; Carotid Artery, Internal - diagnostic imaging ; Carotid Artery, Internal - pathology ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - pathology ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory - physiology ; Neurology ; Neuropsychological Tests ; Psychomotor Performance - physiology ; Regression Analysis ; Risk Factors ; Ultrasonography ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2009-05, Vol.40 (5), p.1590-1596</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009 by American Heart Association 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-e33eab67fdc170f98b180adc64d18756fad51f44761bc6f6ff56612a8b981cb53</citedby><cites>FETCH-LOGICAL-c426t-e33eab67fdc170f98b180adc64d18756fad51f44761bc6f6ff56612a8b981cb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21465146$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19265054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROMERO, José R</creatorcontrib><creatorcontrib>BEISER, Alexa</creatorcontrib><creatorcontrib>SESHADRI, Sudha</creatorcontrib><creatorcontrib>BENJAMIN, Emelia J</creatorcontrib><creatorcontrib>POLAK, Joseph F</creatorcontrib><creatorcontrib>VASAN, Ramachandran S</creatorcontrib><creatorcontrib>AU, Rhoda</creatorcontrib><creatorcontrib>DECARLI, Charles</creatorcontrib><creatorcontrib>WOLF, Philip A</creatorcontrib><title>Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description><![CDATA[Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear.
We studied 1975 Framingham Offspring Study participants free of stroke and dementia with available carotid ultrasound, brain MRI, and neuropsychological testing. We related common and internal carotid artery intima-media thickness and internal carotid stenosis to large white matter hyperintensity (>1 SD above age-specific mean), total brain volume, hippocampal volume, silent cerebral infarcts, and neuropsychological measures of verbal memory, executive function, and nonverbal memory measures.
We observed that internal carotid artery intima-media thickness, but not common carotid artery intima-media thickness, was associated with higher prevalence of silent cerebral infarcts (OR, 1.21; 95% CI, 1.03-1.43; P<0.05), large white matter hyperintensity (OR, 1.19; 95% CI, 1.03-1.38; P<0.05), lower total brain volume (-0.05 per SD; P<0.05), and poorer performance in verbal memory (-0.06 per SD; P<0.05) and nonverbal memory measures (-0.08 per SD; P<0.01), but not with hippocampal volume. Internal carotid stenosis >or=25% was associated with a higher prevalence of large white matter hyperintensity (adjusted OR, 1.77; 95% CI, 1.25-2.53) and lower total brain volume (-0.11 per SD; P=0.042) but not with silent cerebral infarcts or hippocampal volume. Internal carotid stenosis >or=50% was associated with higher prevalence of silent cerebral infarcts (OR, 2.53; 95% CI, 1.17-5.44), large white matter hyperintensity (OR, 2.35; 95% CI, 1.08-5.13), and poorer performance on executive function (-0.39 per SD; P<0.05), but not with total brain volume or hippocampal volume.
Carotid atherosclerosis markers were associated with MRI indices of brain ischemia and aging and with cognitive impairment in a community-based sample of middle-aged adults. Our data suggest that internal carotid artery intima-media thickness may be a better marker for cognitive impairment than common carotid artery intima-media thickness.]]></description><subject>Aged</subject><subject>Aging - physiology</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - psychology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Brain - pathology</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - psychology</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Artery Diseases - complications</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Carotid Artery Diseases - psychology</subject><subject>Carotid Artery, Common - diagnostic imaging</subject><subject>Carotid Artery, Common - pathology</subject><subject>Carotid Artery, Internal - diagnostic imaging</subject><subject>Carotid Artery, Internal - pathology</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - pathology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - physiology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Psychomotor Performance - physiology</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Ultrasonography</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU2P0zAQhi0EYsvCP0DIFzg1xd9JLkih2mUjFq20W87WxLEbo8QpdrpS_z2pWhU42CPNPPPOaF6E3lOyolTRz0-bx4fvN9VdtaKkWEkumZAv0ILOMROKFS_RghBeZkyU5RV6k9IvQgjjhXyNrmjJlCRSLFBaQxwn3-IqTjYecDV1No7J9MffpyX-8VjjOrTe2IRHh79G8AHXyXR28LDE1daH7RJDaPF63AY_-WeL62EHPg42THjTWXwbYZipDgb8NO3bw1v0ykGf7LtzvEY_b28267vs_uFbva7uMyOYmjLLuYVG5a41NCeuLBpaEGiNEi0tcqkctJI6IXJFG6Occk4qRRkUTVlQ00h-jb6cdHf7ZrCtmfeJ0Otd9APEgx7B6_8rwXd6Oz5rlhPJmZgFPp0F4vh7b9OkB5-M7XsIdtwnrXKaK54fJ4kTaOarpWjdZQgl-uiWvrg1Zwp9cmtu-_Dvgn-bzvbMwMczAMlA7yIE49OFY1QoOT_-B019n_k</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>ROMERO, José R</creator><creator>BEISER, Alexa</creator><creator>SESHADRI, Sudha</creator><creator>BENJAMIN, Emelia J</creator><creator>POLAK, Joseph F</creator><creator>VASAN, Ramachandran S</creator><creator>AU, Rhoda</creator><creator>DECARLI, Charles</creator><creator>WOLF, Philip A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090501</creationdate><title>Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study</title><author>ROMERO, José R ; BEISER, Alexa ; SESHADRI, Sudha ; BENJAMIN, Emelia J ; POLAK, Joseph F ; VASAN, Ramachandran S ; AU, Rhoda ; DECARLI, Charles ; WOLF, Philip A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-e33eab67fdc170f98b180adc64d18756fad51f44761bc6f6ff56612a8b981cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aging - physiology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - psychology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Brain - pathology</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - psychology</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Artery Diseases - complications</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Carotid Artery Diseases - psychology</topic><topic>Carotid Artery, Common - diagnostic imaging</topic><topic>Carotid Artery, Common - pathology</topic><topic>Carotid Artery, Internal - diagnostic imaging</topic><topic>Carotid Artery, Internal - pathology</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - pathology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - physiology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Psychomotor Performance - physiology</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Ultrasonography</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROMERO, José R</creatorcontrib><creatorcontrib>BEISER, Alexa</creatorcontrib><creatorcontrib>SESHADRI, Sudha</creatorcontrib><creatorcontrib>BENJAMIN, Emelia J</creatorcontrib><creatorcontrib>POLAK, Joseph F</creatorcontrib><creatorcontrib>VASAN, Ramachandran S</creatorcontrib><creatorcontrib>AU, Rhoda</creatorcontrib><creatorcontrib>DECARLI, Charles</creatorcontrib><creatorcontrib>WOLF, Philip A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROMERO, José R</au><au>BEISER, Alexa</au><au>SESHADRI, Sudha</au><au>BENJAMIN, Emelia J</au><au>POLAK, Joseph F</au><au>VASAN, Ramachandran S</au><au>AU, Rhoda</au><au>DECARLI, Charles</au><au>WOLF, Philip A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>40</volume><issue>5</issue><spage>1590</spage><epage>1596</epage><pages>1590-1596</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract><![CDATA[Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear.
We studied 1975 Framingham Offspring Study participants free of stroke and dementia with available carotid ultrasound, brain MRI, and neuropsychological testing. We related common and internal carotid artery intima-media thickness and internal carotid stenosis to large white matter hyperintensity (>1 SD above age-specific mean), total brain volume, hippocampal volume, silent cerebral infarcts, and neuropsychological measures of verbal memory, executive function, and nonverbal memory measures.
We observed that internal carotid artery intima-media thickness, but not common carotid artery intima-media thickness, was associated with higher prevalence of silent cerebral infarcts (OR, 1.21; 95% CI, 1.03-1.43; P<0.05), large white matter hyperintensity (OR, 1.19; 95% CI, 1.03-1.38; P<0.05), lower total brain volume (-0.05 per SD; P<0.05), and poorer performance in verbal memory (-0.06 per SD; P<0.05) and nonverbal memory measures (-0.08 per SD; P<0.01), but not with hippocampal volume. Internal carotid stenosis >or=25% was associated with a higher prevalence of large white matter hyperintensity (adjusted OR, 1.77; 95% CI, 1.25-2.53) and lower total brain volume (-0.11 per SD; P=0.042) but not with silent cerebral infarcts or hippocampal volume. Internal carotid stenosis >or=50% was associated with higher prevalence of silent cerebral infarcts (OR, 2.53; 95% CI, 1.17-5.44), large white matter hyperintensity (OR, 2.35; 95% CI, 1.08-5.13), and poorer performance on executive function (-0.39 per SD; P<0.05), but not with total brain volume or hippocampal volume.
Carotid atherosclerosis markers were associated with MRI indices of brain ischemia and aging and with cognitive impairment in a community-based sample of middle-aged adults. Our data suggest that internal carotid artery intima-media thickness may be a better marker for cognitive impairment than common carotid artery intima-media thickness.]]></abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19265054</pmid><doi>10.1161/STROKEAHA.108.535245</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 2009-05, Vol.40 (5), p.1590-1596 |
| issn | 0039-2499 1524-4628 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2705324 |
| source | MEDLINE; American Heart Association; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Aging - physiology Atherosclerosis (general aspects, experimental research) Atherosclerosis - complications Atherosclerosis - pathology Atherosclerosis - psychology Biological and medical sciences Blood and lymphatic vessels Brain - pathology Brain Ischemia - complications Brain Ischemia - pathology Brain Ischemia - psychology Cardiology. Vascular system Carotid Arteries - pathology Carotid Artery Diseases - complications Carotid Artery Diseases - pathology Carotid Artery Diseases - psychology Carotid Artery, Common - diagnostic imaging Carotid Artery, Common - pathology Carotid Artery, Internal - diagnostic imaging Carotid Artery, Internal - pathology Carotid Stenosis - diagnostic imaging Carotid Stenosis - pathology Cognition Disorders - etiology Cognition Disorders - psychology Female Humans Magnetic Resonance Imaging Male Medical sciences Memory - physiology Neurology Neuropsychological Tests Psychomotor Performance - physiology Regression Analysis Risk Factors Ultrasonography Vascular diseases and vascular malformations of the nervous system |
| title | Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A20%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carotid%20Artery%20Atherosclerosis,%20MRI%20Indices%20of%20Brain%20Ischemia,%20Aging,%20and%20Cognitive%20Impairment%20The%20Framingham%20Study&rft.jtitle=Stroke%20(1970)&rft.au=ROMERO,%20Jos%C3%A9%20R&rft.date=2009-05-01&rft.volume=40&rft.issue=5&rft.spage=1590&rft.epage=1596&rft.pages=1590-1596&rft.issn=0039-2499&rft.eissn=1524-4628&rft.coden=SJCCA7&rft_id=info:doi/10.1161/STROKEAHA.108.535245&rft_dat=%3Cproquest_pubme%3E67176375%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67176375&rft_id=info:pmid/19265054&rfr_iscdi=true |