Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells

The tauopathies are a diverse class of devastating neurodegenerative disorders, characterized by the hyperphosphorylation and aggregation of the microtubule binding protein tau.  Niemann-Pick type C disease (NPC) is a tauopathy that affects children, and is caused by mutations in intracellular lipid...

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