Taurine Chloramine Activates Nrf2, Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen Peroxide
Hypochlorous acid (HOCl) is toxic and causes cell death. However, this effect is inhibited by reaction with taurine, which generates taurine chloramine (TauCl), thereby protecting the cells from HOCl-generated toxicity. TauCl has been shown to inhibit the production of inflammatory mediators like O2...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2009, Vol.45(1), pp.37-43 |
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| creator | Jang, Jin Sun Piao, Shuyu Cha, Young-Nam Kim, Chaekyun |
| description | Hypochlorous acid (HOCl) is toxic and causes cell death. However, this effect is inhibited by reaction with taurine, which generates taurine chloramine (TauCl), thereby protecting the cells from HOCl-generated toxicity. TauCl has been shown to inhibit the production of inflammatory mediators like O2•−, H2O2 and NO. In this study, RAW 264.7 macrophages treated with TauCl were protected from death caused by H2O2. TauCl increased the expression of peroxiredoxin-1, thioredoxin-1 and heme oxygenase (HO)-1, the anti-oxidant enzymes normally induced by activation of NF-E2-related factor-2 (Nrf2). TauCl increased nuclear translocation of Nrf2 and binding to the anti-oxidant response element. These data suggest that TauCl produced abundantly in the activated neutrophils and released to surrounding cells in the inflamed tissues may induce the expression of cytoprotective anti-oxidant enzymes. Elevation of HO activity via induction of HO-1 expression within neighboring cells may provide protection from cytotoxicity caused by inflammatory oxidants like H2O2. |
| doi_str_mv | 10.3164/jcbn.08-262 |
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Clin. Biochem. Nutr.</addtitle><description>Hypochlorous acid (HOCl) is toxic and causes cell death. However, this effect is inhibited by reaction with taurine, which generates taurine chloramine (TauCl), thereby protecting the cells from HOCl-generated toxicity. TauCl has been shown to inhibit the production of inflammatory mediators like O2•−, H2O2 and NO. In this study, RAW 264.7 macrophages treated with TauCl were protected from death caused by H2O2. TauCl increased the expression of peroxiredoxin-1, thioredoxin-1 and heme oxygenase (HO)-1, the anti-oxidant enzymes normally induced by activation of NF-E2-related factor-2 (Nrf2). TauCl increased nuclear translocation of Nrf2 and binding to the anti-oxidant response element. These data suggest that TauCl produced abundantly in the activated neutrophils and released to surrounding cells in the inflamed tissues may induce the expression of cytoprotective anti-oxidant enzymes. Elevation of HO activity via induction of HO-1 expression within neighboring cells may provide protection from cytotoxicity caused by inflammatory oxidants like H2O2.</description><subject>cell death</subject><subject>heme oxygenase-1</subject><subject>hydrogen peroxide</subject><subject>nuclear factor-erythroid 2-related factor 2</subject><subject>Original</subject><subject>taurine chloramine</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpVkcFr2zAUh8XYWLNup92HYMfVnSTLsnUZBK9bCmXtoTsLWXpOHBwpk-TQ_Pe1ccjai54e7-N7D34IfabkOqeCf9-axl2TKmOCvUELWlUkK0gl3qIFkZRlhBB5gT7EuCWEi0Lw9-iCykKSkhQLdHjUQ-gc4HrT-6B303dpUnfQCSL-E1p2hW-dCaDj2K_uM4pvnvYBYuy8w9pZ_BB8ApMirqHvI26D3-GfoNMG13qIYHFzxKujDX4NDj9A8E-dhY_oXav7CJ9O9RL9_XXzWK-yu_vft_XyLjOiKFMGecN5Ja2UknFR0TKXktucakpa0bBSUs6FLY1opITSFtYwTXJpTGNYwSjNL9GP2bsfmh1YAy4F3at96HY6HJXXnXo9cd1Grf1BsZLwnBWj4OtJEPy_AWJSWz8EN96sxt2MVlKWE_VtpkzwMQZozxsoUVNIagpJkUqNIY30l5dH_WdPqYzAcga2Mek1nAEdUmd6mGW8UHR6Zul5ZjY6KHD5M1NbpVY</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Jang, Jin Sun</creator><creator>Piao, Shuyu</creator><creator>Cha, Young-Nam</creator><creator>Kim, Chaekyun</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Taurine Chloramine Activates Nrf2, Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen Peroxide</title><author>Jang, Jin Sun ; Piao, Shuyu ; Cha, Young-Nam ; Kim, Chaekyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c657t-e3b4489d9992468173994d31a10f6b2791446d7c6b99e7d5dc2a039ccbc252113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>cell death</topic><topic>heme oxygenase-1</topic><topic>hydrogen peroxide</topic><topic>nuclear factor-erythroid 2-related factor 2</topic><topic>Original</topic><topic>taurine chloramine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Jin Sun</creatorcontrib><creatorcontrib>Piao, Shuyu</creatorcontrib><creatorcontrib>Cha, Young-Nam</creatorcontrib><creatorcontrib>Kim, Chaekyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Jin Sun</au><au>Piao, Shuyu</au><au>Cha, Young-Nam</au><au>Kim, Chaekyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taurine Chloramine Activates Nrf2, Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen Peroxide</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>45</volume><issue>1</issue><spage>37</spage><epage>43</epage><pages>37-43</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>Hypochlorous acid (HOCl) is toxic and causes cell death. However, this effect is inhibited by reaction with taurine, which generates taurine chloramine (TauCl), thereby protecting the cells from HOCl-generated toxicity. TauCl has been shown to inhibit the production of inflammatory mediators like O2•−, H2O2 and NO. In this study, RAW 264.7 macrophages treated with TauCl were protected from death caused by H2O2. TauCl increased the expression of peroxiredoxin-1, thioredoxin-1 and heme oxygenase (HO)-1, the anti-oxidant enzymes normally induced by activation of NF-E2-related factor-2 (Nrf2). TauCl increased nuclear translocation of Nrf2 and binding to the anti-oxidant response element. 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| subjects | cell death heme oxygenase-1 hydrogen peroxide nuclear factor-erythroid 2-related factor 2 Original taurine chloramine |
| title | Taurine Chloramine Activates Nrf2, Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen Peroxide |
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