Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis
AIM：To investigate the significance of Thrombospondin-1 （TSP-1） expression and its relationship with angiogenesis during experimental fibrosis. METHODS：Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine （DEN）. The serial sections from liver tissues wer...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2008-04, Vol.14 (14), p.2213-2217 |
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| creator | Elpek, Gulsum-Ozlem Gokhan, Guzide-Ayse Bozova, Sevgi |
| description | AIM：To investigate the significance of Thrombospondin-1 （TSP-1） expression and its relationship with angiogenesis during experimental fibrosis. METHODS：Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine （DEN）. The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS：Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis （GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P 〈 0.05）. Moreover, TSP-1 expression was found to be correlated with angiogenesis （P 〈 0.05）. CONCLUSION：The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 （TGF-β1）, TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. |
| doi_str_mv | 10.3748/wjg.14.2213 |
| format | Article |
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METHODS：Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine （DEN）. The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS：Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis （GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P 〈 0.05）. Moreover, TSP-1 expression was found to be correlated with angiogenesis （P 〈 0.05）. CONCLUSION：The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 （TGF-β1）, TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.14.2213</identifier><identifier>PMID: 18407596</identifier><language>eng</language><publisher>United States: Akdeniz University, Medical School, Department of Pathology,Antalya 07070, Turkey</publisher><subject>Animals ; Antigens, CD34 - biosynthesis ; Diethylnitrosamine - metabolism ; Disease Models, Animal ; Fibrosis - metabolism ; Gene Expression Regulation ; Immunohistochemistry - methods ; Inflammation ; Liver - pathology ; Male ; Neovascularization, Pathologic ; Rapid Communication ; Rats ; Rats, Wistar ; Thrombospondin 1 - biosynthesis ; 免疫组织化学 ; 肝硬化 ; 肝纤维化 ; 血管发生</subject><ispartof>World journal of gastroenterology : WJG, 2008-04, Vol.14 (14), p.2213-2217</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2008 The WJG Press and Baishideng. All rights reserved. 2008</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-a20384f9cba666d468d30fdac547bef8e25b92309f4d093162730cf9bd3770943</citedby><cites>FETCH-LOGICAL-c435t-a20384f9cba666d468d30fdac547bef8e25b92309f4d093162730cf9bd3770943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703847/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703847/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18407596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elpek, Gulsum-Ozlem</creatorcontrib><creatorcontrib>Gokhan, Guzide-Ayse</creatorcontrib><creatorcontrib>Bozova, Sevgi</creatorcontrib><title>Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM：To investigate the significance of Thrombospondin-1 （TSP-1） expression and its relationship with angiogenesis during experimental fibrosis. METHODS：Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine （DEN）. The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS：Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis （GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P 〈 0.05）. Moreover, TSP-1 expression was found to be correlated with angiogenesis （P 〈 0.05）. CONCLUSION：The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 （TGF-β1）, TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver.</description><subject>Animals</subject><subject>Antigens, CD34 - biosynthesis</subject><subject>Diethylnitrosamine - metabolism</subject><subject>Disease Models, Animal</subject><subject>Fibrosis - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Immunohistochemistry - methods</subject><subject>Inflammation</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Neovascularization, Pathologic</subject><subject>Rapid Communication</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thrombospondin 1 - biosynthesis</subject><subject>免疫组织化学</subject><subject>肝硬化</subject><subject>肝纤维化</subject><subject>血管发生</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1rGzEQxUVJqZ20p9zLEnIL644-drW6FELIRyFQKO5ZaLXSrpy15Ep23Pz31WKTJqc5vB_vvZlB6BzDgnLWfNuv-gVmC0Iw_YDmeYiSNAxO0BwD8FJQwmfoNKUVAKG0Ip_QDGedV6Keo1_LIYZ1G9Im-M75Ehfm7yaalFzwhQ4xmlFtTSr2bjsUyvcu9Mab5FLh_ISa6NbGb9VYaBfjELLyGX20akzmy3Geod93t8ubh_Lx5_2Pm-vHUjNabUtFgDbMCt2quq47VjcdBdspXTHeGtsYUrWCUBCWdSAorgmnoK1oO8o5CEbP0PeD72bXrk2nc42oRrnJjVR8kUE5-V7xbpB9eJaET8k8G1weDPbK27ybXIVd9LmyzCclAA1mgEnGrg6YjiGlaOxrBAY5fWDCJWZy-kCmv75t9Z89njwDF0e7Ifj-j8u5rdJP1o1maiY4YEH_AfTljzE</recordid><startdate>20080414</startdate><enddate>20080414</enddate><creator>Elpek, Gulsum-Ozlem</creator><creator>Gokhan, Guzide-Ayse</creator><creator>Bozova, Sevgi</creator><general>Akdeniz University, Medical School, Department of Pathology,Antalya 07070, Turkey</general><general>The WJG Press and Baishideng</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20080414</creationdate><title>Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis</title><author>Elpek, Gulsum-Ozlem ; Gokhan, Guzide-Ayse ; Bozova, Sevgi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-a20384f9cba666d468d30fdac547bef8e25b92309f4d093162730cf9bd3770943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antigens, CD34 - biosynthesis</topic><topic>Diethylnitrosamine - metabolism</topic><topic>Disease Models, Animal</topic><topic>Fibrosis - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Immunohistochemistry - methods</topic><topic>Inflammation</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Neovascularization, Pathologic</topic><topic>Rapid Communication</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Thrombospondin 1 - biosynthesis</topic><topic>免疫组织化学</topic><topic>肝硬化</topic><topic>肝纤维化</topic><topic>血管发生</topic><toplevel>online_resources</toplevel><creatorcontrib>Elpek, Gulsum-Ozlem</creatorcontrib><creatorcontrib>Gokhan, Guzide-Ayse</creatorcontrib><creatorcontrib>Bozova, Sevgi</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elpek, Gulsum-Ozlem</au><au>Gokhan, Guzide-Ayse</au><au>Bozova, Sevgi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2008-04-14</date><risdate>2008</risdate><volume>14</volume><issue>14</issue><spage>2213</spage><epage>2217</epage><pages>2213-2217</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM：To investigate the significance of Thrombospondin-1 （TSP-1） expression and its relationship with angiogenesis during experimental fibrosis. METHODS：Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine （DEN）. The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS：Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis （GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P 〈 0.05）. Moreover, TSP-1 expression was found to be correlated with angiogenesis （P 〈 0.05）. CONCLUSION：The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 （TGF-β1）, TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver.</abstract><cop>United States</cop><pub>Akdeniz University, Medical School, Department of Pathology,Antalya 07070, Turkey</pub><pmid>18407596</pmid><doi>10.3748/wjg.14.2213</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens, CD34 - biosynthesis Diethylnitrosamine - metabolism Disease Models, Animal Fibrosis - metabolism Gene Expression Regulation Immunohistochemistry - methods Inflammation Liver - pathology Male Neovascularization, Pathologic Rapid Communication Rats Rats, Wistar Thrombospondin 1 - biosynthesis 免疫组织化学 肝硬化 肝纤维化 血管发生 |
| title | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis |
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