Necrotizing enterocolitis： A multifactorial disease with no cure
Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm bir...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2008-04, Vol.14 (14), p.2142-2161 |
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| creator | Schnabl, Kareena-L Van Aerde, John-E Thomson, Alan-Br Clandinin, Michael-T |
| description | Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics. |
| doi_str_mv | 10.3748/wjg.14.2142 |
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Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.14.2142</identifier><identifier>PMID: 18407587</identifier><language>eng</language><publisher>United States: Nutrition and Metabolism Research Groups,Department of Medicine, University of Alberta, Edmonton T6G 2P5, Canada%Department of Pediatrics, University of Alberta, Edmonton T6G 2P5, Canada%Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton T6G 2P5,Canada%Alberta Institute for Human Nutrition,University of Alberta, Edmonton T6G 2P5, Canada</publisher><subject>Eicosanoids - metabolism ; Enterocolitis, Necrotizing - diagnosis ; Enterocolitis, Necrotizing - therapy ; Gastroenterology - methods ; Genetic Predisposition to Disease ; Humans ; Hypoxia ; Infant, Newborn ; Inflammation ; Intestines - immunology ; Ischemia - pathology ; Milk, Human - metabolism ; Reactive Oxygen Species ; Review ; Risk Factors ; Signal Transduction ; Treatment Outcome ; 临床表现 ; 结肠炎 ; 致病因素 ; 血管炎症</subject><ispartof>World journal of gastroenterology : WJG, 2008-04, Vol.14 (14), p.2142-2161</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2008 The WJG Press and Baishideng. All rights reserved. 2008</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-b28c025ac5bb5be36146db646898060160150fd39cd27774cb182d30fadfce693</citedby><cites>FETCH-LOGICAL-c435t-b28c025ac5bb5be36146db646898060160150fd39cd27774cb182d30fadfce693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703838/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703838/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18407587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schnabl, Kareena-L</creatorcontrib><creatorcontrib>Van Aerde, John-E</creatorcontrib><creatorcontrib>Thomson, Alan-Br</creatorcontrib><creatorcontrib>Clandinin, Michael-T</creatorcontrib><title>Necrotizing enterocolitis： A multifactorial disease with no cure</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics.</description><subject>Eicosanoids - metabolism</subject><subject>Enterocolitis, Necrotizing - diagnosis</subject><subject>Enterocolitis, Necrotizing - therapy</subject><subject>Gastroenterology - methods</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Infant, Newborn</subject><subject>Inflammation</subject><subject>Intestines - immunology</subject><subject>Ischemia - pathology</subject><subject>Milk, Human - metabolism</subject><subject>Reactive Oxygen Species</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Signal Transduction</subject><subject>Treatment Outcome</subject><subject>临床表现</subject><subject>结肠炎</subject><subject>致病因素</subject><subject>血管炎症</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9O3DAQxi0EgmXhxL2KUMWlyjL-k9i5IAGCFgm1l_ZsOY6T9TZrg510VR6FZ-Gd-gp4tSsoGktzmJ---TwfQicYZpQzcb5adDPMZgQzsoMmhOAqJ4LBLppgAJ5XlPADdBjjAoBQWpB9dIDTnBeCT9DVd6ODH-yTdV1m3GCC1763g43_Xp6zy2w59oNtlR58sKrPGhuNiiZb2WGeOZ_pMZgjtNeqPprjbZ-iX7c3P6-_5fc_vt5dX97nmtFiyGsiNJBC6aKui9rQErOyqUtWikpACTi9AtqGVrohnHOmayxIQ6FVTatNWdEputjoPoz10jQ6uQ2qlw_BLlX4K72y8uPE2bns_B9JOFCRaoo-bwRWyrXKdXLhx-CSZZlOSAAEZgA0YWfbPcE_jiYOcmmjNn2vnPFjlBwKDLTCCfyyAdMFYwymffOCQa6jWetKzOQ6mkR_-t_-O7vNIgGnW7m5d91jCkTWSv9ubW_WX6g4pLWv5juW8A</recordid><startdate>20080414</startdate><enddate>20080414</enddate><creator>Schnabl, Kareena-L</creator><creator>Van Aerde, John-E</creator><creator>Thomson, Alan-Br</creator><creator>Clandinin, Michael-T</creator><general>Nutrition and Metabolism Research Groups,Department of Medicine, University of Alberta, Edmonton T6G 2P5, Canada%Department of Pediatrics, University of Alberta, Edmonton T6G 2P5, Canada%Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton T6G 2P5,Canada%Alberta Institute for Human Nutrition,University of Alberta, Edmonton T6G 2P5, Canada</general><general>The WJG Press and Baishideng</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20080414</creationdate><title>Necrotizing enterocolitis： A multifactorial disease with no cure</title><author>Schnabl, Kareena-L ; 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Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. 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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Eicosanoids - metabolism Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - therapy Gastroenterology - methods Genetic Predisposition to Disease Humans Hypoxia Infant, Newborn Inflammation Intestines - immunology Ischemia - pathology Milk, Human - metabolism Reactive Oxygen Species Review Risk Factors Signal Transduction Treatment Outcome 临床表现 结肠炎 致病因素 血管炎症 |
| title | Necrotizing enterocolitis： A multifactorial disease with no cure |
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