Antiviral Immunity Directed by Small RNAs
Plants and invertebrates can protect themselves from viral infection through RNA silencing. This antiviral immunity involves production of virus-derived small interfering RNAs (viRNAs) and results in specific silencing of viruses by viRNA-guided effector complexes. The proteins required for viRNA pr...
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| Veröffentlicht in: | Cell 2007-08, Vol.130 (3), p.413-426 |
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| container_title | Cell |
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| creator | Ding, Shou-Wei Voinnet, Olivier |
| description | Plants and invertebrates can protect themselves from viral infection through RNA silencing. This antiviral immunity involves production of virus-derived small interfering RNAs (viRNAs) and results in specific silencing of viruses by viRNA-guided effector complexes. The proteins required for viRNA production as well as several key downstream components of the antiviral immunity pathway have been identified in plants, flies, and worms. Meanwhile, viral mechanisms to suppress this small RNA-directed immunity by viruses are being elucidated, thereby illuminating an ongoing molecular arms race that likely impacts the evolution of both viral and host genomes. |
| doi_str_mv | 10.1016/j.cell.2007.07.039 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cellular Biology Humans Immunity, Innate - genetics Life Sciences RNA, Small Interfering - chemistry RNA, Small Interfering - physiology Virus Diseases - genetics Virus Diseases - immunology Virus Diseases - virology |
| title | Antiviral Immunity Directed by Small RNAs |
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