Age‐related myelin dynamics revealed by increased oligodendrogenesis and short internodes
Summary Aging is associated with many functional and morphological central nervous system changes. It is important to distinguish between changes created by normal aging and those caused by disease. In the present study we characterized myelin changes within the murine rubrospinal tract and found th...
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| Veröffentlicht in: | Aging cell 2009-04, Vol.8 (2), p.201-213 |
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| creator | Lasiene, Jurate Matsui, Aya Sawa, Yuhito Wong, Fernando Horner, Philip J. |
| description | Summary
Aging is associated with many functional and morphological central nervous system changes. It is important to distinguish between changes created by normal aging and those caused by disease. In the present study we characterized myelin changes within the murine rubrospinal tract and found that internode lengths significantly decrease as a function of age which suggests active remyelination. We also analyzed the proliferation, distribution and phenotypic fate of dividing cells with Bromodeoxyuridine (5‐bromo‐2‐deoxyuridine, BrdU). The data reveal a decrease in glial cell proliferation from 1 to 6, 14 and 21 months of age in gray matter 4 weeks post‐BrdU injections. However, we found an increase in gliogenesis at 21st month in white matter of the spinal cord. Half of newly generated cells expressed NG2. Most cells were positive for the early oligodendrocyte marker Olig2 and a few also expressed CC1. Very few cells ever became positive for the astrocytic markers S100β or GFAP. These data demonstrate ongoing oligodendrogenesis and myelinogenesis as a function of age in the spinal cord. |
| doi_str_mv | 10.1111/j.1474-9726.2009.00462.x |
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Aging is associated with many functional and morphological central nervous system changes. It is important to distinguish between changes created by normal aging and those caused by disease. In the present study we characterized myelin changes within the murine rubrospinal tract and found that internode lengths significantly decrease as a function of age which suggests active remyelination. We also analyzed the proliferation, distribution and phenotypic fate of dividing cells with Bromodeoxyuridine (5‐bromo‐2‐deoxyuridine, BrdU). The data reveal a decrease in glial cell proliferation from 1 to 6, 14 and 21 months of age in gray matter 4 weeks post‐BrdU injections. However, we found an increase in gliogenesis at 21st month in white matter of the spinal cord. Half of newly generated cells expressed NG2. Most cells were positive for the early oligodendrocyte marker Olig2 and a few also expressed CC1. Very few cells ever became positive for the astrocytic markers S100β or GFAP. These data demonstrate ongoing oligodendrogenesis and myelinogenesis as a function of age in the spinal cord.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/j.1474-9726.2009.00462.x</identifier><identifier>PMID: 19338498</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>aging ; Aging - metabolism ; Aging - pathology ; Animals ; Basic Helix-Loop-Helix Transcription Factors - analysis ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Biomarkers - analysis ; Biomarkers - metabolism ; Bromodeoxyuridine ; Cell Proliferation ; Efferent Pathways - metabolism ; Efferent Pathways - ultrastructure ; Female ; Intracellular Signaling Peptides and Proteins - analysis ; Intracellular Signaling Peptides and Proteins - metabolism ; Mice ; Mice, Inbred C57BL ; murine ; myelin ; Myelin Sheath - metabolism ; Myelin Sheath - ultrastructure ; Nerve Fibers, Myelinated - metabolism ; Nerve Fibers, Myelinated - ultrastructure ; Nerve Regeneration - physiology ; Nerve Tissue Proteins - analysis ; Nerve Tissue Proteins - metabolism ; Oligodendrocyte Transcription Factor 2 ; oligodendrocytes ; Oligodendroglia - metabolism ; Oligodendroglia - ultrastructure ; Ranvier's Nodes - metabolism ; Ranvier's Nodes - ultrastructure ; Red Nucleus - metabolism ; Red Nucleus - ultrastructure ; remyelination ; spinal cord ; Spinal Cord - metabolism ; Spinal Cord - ultrastructure</subject><ispartof>Aging cell, 2009-04, Vol.8 (2), p.201-213</ispartof><rights>2009 The Authors. Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5692-6d836b1c4b83cab131e4e8c5b7e11b53b02d6086a9fd2cb443e7570e3e22845b3</citedby><cites>FETCH-LOGICAL-c5692-6d836b1c4b83cab131e4e8c5b7e11b53b02d6086a9fd2cb443e7570e3e22845b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703583/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703583/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1474-9726.2009.00462.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19338498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lasiene, Jurate</creatorcontrib><creatorcontrib>Matsui, Aya</creatorcontrib><creatorcontrib>Sawa, Yuhito</creatorcontrib><creatorcontrib>Wong, Fernando</creatorcontrib><creatorcontrib>Horner, Philip J.</creatorcontrib><title>Age‐related myelin dynamics revealed by increased oligodendrogenesis and short internodes</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Summary
Aging is associated with many functional and morphological central nervous system changes. It is important to distinguish between changes created by normal aging and those caused by disease. In the present study we characterized myelin changes within the murine rubrospinal tract and found that internode lengths significantly decrease as a function of age which suggests active remyelination. We also analyzed the proliferation, distribution and phenotypic fate of dividing cells with Bromodeoxyuridine (5‐bromo‐2‐deoxyuridine, BrdU). The data reveal a decrease in glial cell proliferation from 1 to 6, 14 and 21 months of age in gray matter 4 weeks post‐BrdU injections. However, we found an increase in gliogenesis at 21st month in white matter of the spinal cord. Half of newly generated cells expressed NG2. Most cells were positive for the early oligodendrocyte marker Olig2 and a few also expressed CC1. Very few cells ever became positive for the astrocytic markers S100β or GFAP. These data demonstrate ongoing oligodendrogenesis and myelinogenesis as a function of age in the spinal cord.</description><subject>aging</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors - analysis</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - metabolism</subject><subject>Bromodeoxyuridine</subject><subject>Cell Proliferation</subject><subject>Efferent Pathways - metabolism</subject><subject>Efferent Pathways - ultrastructure</subject><subject>Female</subject><subject>Intracellular Signaling Peptides and Proteins - analysis</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>murine</subject><subject>myelin</subject><subject>Myelin Sheath - metabolism</subject><subject>Myelin Sheath - ultrastructure</subject><subject>Nerve Fibers, Myelinated - metabolism</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Nerve Regeneration - physiology</subject><subject>Nerve Tissue Proteins - analysis</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Oligodendrocyte Transcription Factor 2</subject><subject>oligodendrocytes</subject><subject>Oligodendroglia - metabolism</subject><subject>Oligodendroglia - ultrastructure</subject><subject>Ranvier's Nodes - metabolism</subject><subject>Ranvier's Nodes - ultrastructure</subject><subject>Red Nucleus - metabolism</subject><subject>Red Nucleus - ultrastructure</subject><subject>remyelination</subject><subject>spinal cord</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord - ultrastructure</subject><issn>1474-9718</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuOEzEQRS0EYoaBX0C9YpfGz273AqQoGh5SJDawYmH5Uck4ctuD3ZmZ3vEJfCNfgkOiADu8cVn31nWpDkINwS2p5_WuJbzni6GnXUsxHlqMeUfbh0fo8iw8PtdEXqBnpewwJv2A2VN0QQbGJB_kJfq63MLP7z8yBD2Ba8YZgo-Nm6MevS1NhjvQoQpmbny0GXSpjxT8NjmILqctRCi-NDq6ptykPFXbBDlWuTxHTzY6FHhxuq_Ql3fXn1cfFutP7z-uluuFFd1AF52TrDPEciOZ1YYwAhykFaYHQoxgBlPXYdnpYeOoNZwz6EWPgQGlkgvDrtDbY-7t3ozgLMQp66Busx91nlXSXv2rRH-jtulO0R4zIVkNeHUKyOnbHsqkRl8shKAjpH1RFAshJBHVKI9Gm1MpGTbnTwhWBzJqpw5LVwcA6kBG_SajHmrry7-H_NN4QlENb46Gex9g_u9gtVxdr2vFfgH5nKCc</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Lasiene, Jurate</creator><creator>Matsui, Aya</creator><creator>Sawa, Yuhito</creator><creator>Wong, Fernando</creator><creator>Horner, Philip J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>200904</creationdate><title>Age‐related myelin dynamics revealed by increased oligodendrogenesis and short internodes</title><author>Lasiene, Jurate ; Matsui, Aya ; Sawa, Yuhito ; Wong, Fernando ; Horner, Philip J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5692-6d836b1c4b83cab131e4e8c5b7e11b53b02d6086a9fd2cb443e7570e3e22845b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>aging</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors - analysis</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - metabolism</topic><topic>Bromodeoxyuridine</topic><topic>Cell Proliferation</topic><topic>Efferent Pathways - metabolism</topic><topic>Efferent Pathways - ultrastructure</topic><topic>Female</topic><topic>Intracellular Signaling Peptides and Proteins - analysis</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>murine</topic><topic>myelin</topic><topic>Myelin Sheath - metabolism</topic><topic>Myelin Sheath - ultrastructure</topic><topic>Nerve Fibers, Myelinated - metabolism</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Nerve Regeneration - physiology</topic><topic>Nerve Tissue Proteins - analysis</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Oligodendrocyte Transcription Factor 2</topic><topic>oligodendrocytes</topic><topic>Oligodendroglia - metabolism</topic><topic>Oligodendroglia - ultrastructure</topic><topic>Ranvier's Nodes - metabolism</topic><topic>Ranvier's Nodes - ultrastructure</topic><topic>Red Nucleus - metabolism</topic><topic>Red Nucleus - ultrastructure</topic><topic>remyelination</topic><topic>spinal cord</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lasiene, Jurate</creatorcontrib><creatorcontrib>Matsui, Aya</creatorcontrib><creatorcontrib>Sawa, Yuhito</creatorcontrib><creatorcontrib>Wong, Fernando</creatorcontrib><creatorcontrib>Horner, Philip J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lasiene, Jurate</au><au>Matsui, Aya</au><au>Sawa, Yuhito</au><au>Wong, Fernando</au><au>Horner, Philip J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age‐related myelin dynamics revealed by increased oligodendrogenesis and short internodes</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2009-04</date><risdate>2009</risdate><volume>8</volume><issue>2</issue><spage>201</spage><epage>213</epage><pages>201-213</pages><issn>1474-9718</issn><eissn>1474-9726</eissn><abstract>Summary
Aging is associated with many functional and morphological central nervous system changes. It is important to distinguish between changes created by normal aging and those caused by disease. In the present study we characterized myelin changes within the murine rubrospinal tract and found that internode lengths significantly decrease as a function of age which suggests active remyelination. We also analyzed the proliferation, distribution and phenotypic fate of dividing cells with Bromodeoxyuridine (5‐bromo‐2‐deoxyuridine, BrdU). The data reveal a decrease in glial cell proliferation from 1 to 6, 14 and 21 months of age in gray matter 4 weeks post‐BrdU injections. However, we found an increase in gliogenesis at 21st month in white matter of the spinal cord. Half of newly generated cells expressed NG2. Most cells were positive for the early oligodendrocyte marker Olig2 and a few also expressed CC1. Very few cells ever became positive for the astrocytic markers S100β or GFAP. These data demonstrate ongoing oligodendrogenesis and myelinogenesis as a function of age in the spinal cord.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19338498</pmid><doi>10.1111/j.1474-9726.2009.00462.x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | aging Aging - metabolism Aging - pathology Animals Basic Helix-Loop-Helix Transcription Factors - analysis Basic Helix-Loop-Helix Transcription Factors - metabolism Biomarkers - analysis Biomarkers - metabolism Bromodeoxyuridine Cell Proliferation Efferent Pathways - metabolism Efferent Pathways - ultrastructure Female Intracellular Signaling Peptides and Proteins - analysis Intracellular Signaling Peptides and Proteins - metabolism Mice Mice, Inbred C57BL murine myelin Myelin Sheath - metabolism Myelin Sheath - ultrastructure Nerve Fibers, Myelinated - metabolism Nerve Fibers, Myelinated - ultrastructure Nerve Regeneration - physiology Nerve Tissue Proteins - analysis Nerve Tissue Proteins - metabolism Oligodendrocyte Transcription Factor 2 oligodendrocytes Oligodendroglia - metabolism Oligodendroglia - ultrastructure Ranvier's Nodes - metabolism Ranvier's Nodes - ultrastructure Red Nucleus - metabolism Red Nucleus - ultrastructure remyelination spinal cord Spinal Cord - metabolism Spinal Cord - ultrastructure |
| title | Age‐related myelin dynamics revealed by increased oligodendrogenesis and short internodes |
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