Absence of Nuclear Receptors for Oxysterols Liver X Receptor Induces Ovarian Hyperstimulation Syndrome in Mice

Ovarian hyperstimulation syndrome is a frequent complication occurring during in vitro fertilization cycles. It is characterized by a massive ovarian enlargement associated with an accumulation of extra vascular fluid. Here we show that liver X receptor (LXR)-α and LXR-β deficient mice present many...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-07, Vol.150 (7), p.3369-3375
Hauptverfasser:	Mouzat, Kevin, Volat, Fanny, Baron, Silvère, Alves, Georges, Pommier, Aurélien J. C, Volle, David H, Marceau, Geoffroy, DeHaze, Angélique, Déchelotte, Pierre, Duggavathi, Raj, Caira, Françoise, Lobaccaro, Jean-Marc A
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Biological and medical sciences Chorionic Gonadotropin - pharmacology Deregulation DNA-Binding Proteins - deficiency DNA-Binding Proteins - physiology Enlargement Estradiol - biosynthesis Female Fundamental and applied biological sciences. Psychology Gonadotropins Hydrocarbons, Fluorinated - pharmacology In vitro fertilization Inflammation - physiopathology Liver Liver X Receptors Mice Mice, Knockout Nuclear receptors Orphan Nuclear Receptors Ovarian hyperstimulation syndrome Ovarian Hyperstimulation Syndrome - etiology Ovarian Hyperstimulation Syndrome - pathology Ovulation Ovulation Induction Pituitary (anterior) Receptors Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - physiology Sex hormones Steroidogenesis Sulfonamides - pharmacology Transgenic mice Vertebrates: endocrinology
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