Spatial reference and working memory across the lifespan of male Fischer 344 rats
Abstract Loss of mnemonic function is among the earliest and most disconcerting consequences of the aging process. This study was designed to provide a comprehensive profile of spatial mnemonic abilities in male Fischer 344 (F344) rats across the lifespan. Young, middle-aged, and aged F344 rats were...
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| Veröffentlicht in: | Neurobiology of aging 2009-04, Vol.30 (4), p.646-655 |
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| creator | Bizon, J.L LaSarge, C.L Montgomery, K.S McDermott, A.N Setlow, B Griffith, W.H |
| description | Abstract Loss of mnemonic function is among the earliest and most disconcerting consequences of the aging process. This study was designed to provide a comprehensive profile of spatial mnemonic abilities in male Fischer 344 (F344) rats across the lifespan. Young, middle-aged, and aged F344 rats were trained in spatial reference and working memory versions of the water maze task. There was a progressive age-related decline in spatial reference memory across the lifespan. Reliable individual differences were observed among aged rats, with some aged rats performing as well as young cohorts and others performing outside this range. An age-related delay-dependent decline was observed on a working memory version of the water maze task although no relationship between performance on reference and working memory tasks was present. Notably, middle-aged rats were impaired relative to young on both tasks. Together these data demonstrate that individual differences in spatial reference memory exist among aged F344 rats and provide novel data demonstrating an unrelated decline in working memory across the lifespan, suggesting that age-related mnemonic dysfunction may occur across multiple brain systems. |
| doi_str_mv | 10.1016/j.neurobiolaging.2007.08.004 |
| format | Article |
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This study was designed to provide a comprehensive profile of spatial mnemonic abilities in male Fischer 344 (F344) rats across the lifespan. Young, middle-aged, and aged F344 rats were trained in spatial reference and working memory versions of the water maze task. There was a progressive age-related decline in spatial reference memory across the lifespan. Reliable individual differences were observed among aged rats, with some aged rats performing as well as young cohorts and others performing outside this range. An age-related delay-dependent decline was observed on a working memory version of the water maze task although no relationship between performance on reference and working memory tasks was present. Notably, middle-aged rats were impaired relative to young on both tasks. Together these data demonstrate that individual differences in spatial reference memory exist among aged F344 rats and provide novel data demonstrating an unrelated decline in working memory across the lifespan, suggesting that age-related mnemonic dysfunction may occur across multiple brain systems.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2007.08.004</identifier><identifier>PMID: 17889407</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aging ; Aging - physiology ; Aging - psychology ; Animals ; Biological and medical sciences ; Cognitive decline ; Cues ; Development. Senescence. Regeneration. Transplantation ; Disease Models, Animal ; Disease Progression ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - physiopathology ; Internal Medicine ; Longevity - physiology ; Male ; Maze Learning - physiology ; Memory Disorders - diagnosis ; Memory Disorders - physiopathology ; Memory, Short-Term - physiology ; Nerve Net - physiopathology ; Neurology ; Neuropsychological Tests ; Orientation - physiology ; Rats ; Rats, Inbred F344 ; Sex Factors ; Space Perception - physiology ; Spatial learning ; Vertebrates: nervous system and sense organs ; Working memory</subject><ispartof>Neurobiology of aging, 2009-04, Vol.30 (4), p.646-655</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-85ad3e70aa0b730d8fb4cd0074b9f49c3149a1df525f97fe44fb7d2907e039633</citedby><cites>FETCH-LOGICAL-c644t-85ad3e70aa0b730d8fb4cd0074b9f49c3149a1df525f97fe44fb7d2907e039633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2007.08.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23924581$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17889407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bizon, J.L</creatorcontrib><creatorcontrib>LaSarge, C.L</creatorcontrib><creatorcontrib>Montgomery, K.S</creatorcontrib><creatorcontrib>McDermott, A.N</creatorcontrib><creatorcontrib>Setlow, B</creatorcontrib><creatorcontrib>Griffith, W.H</creatorcontrib><title>Spatial reference and working memory across the lifespan of male Fischer 344 rats</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Loss of mnemonic function is among the earliest and most disconcerting consequences of the aging process. This study was designed to provide a comprehensive profile of spatial mnemonic abilities in male Fischer 344 (F344) rats across the lifespan. Young, middle-aged, and aged F344 rats were trained in spatial reference and working memory versions of the water maze task. There was a progressive age-related decline in spatial reference memory across the lifespan. Reliable individual differences were observed among aged rats, with some aged rats performing as well as young cohorts and others performing outside this range. An age-related delay-dependent decline was observed on a working memory version of the water maze task although no relationship between performance on reference and working memory tasks was present. Notably, middle-aged rats were impaired relative to young on both tasks. Together these data demonstrate that individual differences in spatial reference memory exist among aged F344 rats and provide novel data demonstrating an unrelated decline in working memory across the lifespan, suggesting that age-related mnemonic dysfunction may occur across multiple brain systems.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Aging - psychology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cognitive decline</subject><subject>Cues</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - physiopathology</subject><subject>Internal Medicine</subject><subject>Longevity - physiology</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - physiopathology</subject><subject>Memory, Short-Term - physiology</subject><subject>Nerve Net - physiopathology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Orientation - physiology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Sex Factors</subject><subject>Space Perception - physiology</subject><subject>Spatial learning</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Working memory</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEotvCKyAfgFvCOHbiREKVUMUCUiWECmfLcca73ib2YidF-_Z12FWhnDj54M__jOebLHtNoaBA63e7wuEcfGf9oDbWbYoSQBTQFAD8SbaiVdXklLfiabYC2oqcVw2cZecx7iCBXNTPszMqmqblIFbZt5u9mqwaSECDAZ1GolxPfvlwm7LJiKMPB6J08DGSaYtksAbjXjniDRnVgGRto95iIIxzEtQUX2TPjBoivjydF9mP9cfvV5_z66-fvlx9uM51zfmUN5XqGQpQCjrBoG9Mx3W_dNi1hreapT8o2puqrEwrDHJuOtGXLQgE1taMXWSXx9z93I3Ya3RTUIPcBzuqcJBeWfn4xtmt3Pg7WQpgvIEU8PYUEPzPGeMkx_QVHAbl0M9R1olr2noB3x_B31NIg3ooQkEuTuROPnYiFycSGpmcpOev_m70z-OThAS8OQEqajWYoJy28YErWVsmiTRx6yOHaax3FoOM2i7KehtQT7L39n87uvwnSA_W2VT7Fg8Yd34OLqmTVMZSgrxZ9mhZIxAAjFWU3QOqhck-</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Bizon, J.L</creator><creator>LaSarge, C.L</creator><creator>Montgomery, K.S</creator><creator>McDermott, A.N</creator><creator>Setlow, B</creator><creator>Griffith, W.H</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>Spatial reference and working memory across the lifespan of male Fischer 344 rats</title><author>Bizon, J.L ; LaSarge, C.L ; Montgomery, K.S ; McDermott, A.N ; Setlow, B ; Griffith, W.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c644t-85ad3e70aa0b730d8fb4cd0074b9f49c3149a1df525f97fe44fb7d2907e039633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Aging - psychology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cognitive decline</topic><topic>Cues</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - physiopathology</topic><topic>Internal Medicine</topic><topic>Longevity - physiology</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - physiopathology</topic><topic>Memory, Short-Term - physiology</topic><topic>Nerve Net - physiopathology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Orientation - physiology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Sex Factors</topic><topic>Space Perception - physiology</topic><topic>Spatial learning</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bizon, J.L</creatorcontrib><creatorcontrib>LaSarge, C.L</creatorcontrib><creatorcontrib>Montgomery, K.S</creatorcontrib><creatorcontrib>McDermott, A.N</creatorcontrib><creatorcontrib>Setlow, B</creatorcontrib><creatorcontrib>Griffith, W.H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bizon, J.L</au><au>LaSarge, C.L</au><au>Montgomery, K.S</au><au>McDermott, A.N</au><au>Setlow, B</au><au>Griffith, W.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial reference and working memory across the lifespan of male Fischer 344 rats</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>30</volume><issue>4</issue><spage>646</spage><epage>655</epage><pages>646-655</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Abstract Loss of mnemonic function is among the earliest and most disconcerting consequences of the aging process. This study was designed to provide a comprehensive profile of spatial mnemonic abilities in male Fischer 344 (F344) rats across the lifespan. Young, middle-aged, and aged F344 rats were trained in spatial reference and working memory versions of the water maze task. There was a progressive age-related decline in spatial reference memory across the lifespan. Reliable individual differences were observed among aged rats, with some aged rats performing as well as young cohorts and others performing outside this range. An age-related delay-dependent decline was observed on a working memory version of the water maze task although no relationship between performance on reference and working memory tasks was present. Notably, middle-aged rats were impaired relative to young on both tasks. 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| subjects | Aging Aging - physiology Aging - psychology Animals Biological and medical sciences Cognitive decline Cues Development. Senescence. Regeneration. Transplantation Disease Models, Animal Disease Progression Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - physiopathology Internal Medicine Longevity - physiology Male Maze Learning - physiology Memory Disorders - diagnosis Memory Disorders - physiopathology Memory, Short-Term - physiology Nerve Net - physiopathology Neurology Neuropsychological Tests Orientation - physiology Rats Rats, Inbred F344 Sex Factors Space Perception - physiology Spatial learning Vertebrates: nervous system and sense organs Working memory |
| title | Spatial reference and working memory across the lifespan of male Fischer 344 rats |
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