Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons

William Talbot and colleagues show that a kinesin motor protein, Kif1b, is required for the specific localization of mRNAs that encode myelin proteins in central nervous system glia and mediates the development of myelinated axons. Kif1b has previously been linked to the susceptibility of multiple s...

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Veröffentlicht in:	Nature genetics 2009-07, Vol.41 (7), p.854-858
Hauptverfasser:	Lyons, David A, Naylor, Stephen G, Scholze, Anja, Talbot, William S
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Axonal transport Axons - metabolism Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Danio rerio Disease Freshwater Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Human Genetics Humans Kinesin - genetics Kinesin - metabolism letter Messenger RNA Molecular Sequence Data Multiple Sclerosis Myelin Basic Protein - genetics Myelin Basic Protein - metabolism Myelin sheath Myelin Sheath - metabolism Nervous system Oligodendroglia Oligodendroglia - metabolism Physiological aspects Ribonucleic acid RNA Studies Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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