High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus

Interferon α (IFN- α ) levels are elevated in many patients with systemic lupus erythematosus (SLE); however it is not known whether high serum IFN- α activity is a cause or a result of the disease. We studied 266 SLE patients and 405 of their healthy relatives, and frequently found high serum IFN-...

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Veröffentlicht in:	Genes and immunity 2007-09, Vol.8 (6), p.492-502
Hauptverfasser:	Niewold, T B, Hua, J, Lehman, T J A, Harley, J B, Crow, M K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Antinuclear - blood Antibodies, Antinuclear - immunology Autoantibodies Autoantibodies - blood Autoantibodies - immunology Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Cell Line Double-stranded RNA Female Gene Expression Genetic aspects Heritability Human Genetics Humans Immunology Interferon alpha Interferon-alpha - blood Interferon-alpha - genetics Interferon-alpha - immunology Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Male original-article Physiological aspects Risk Factors RNA-binding protein RNA-Binding Proteins - immunology Systemic lupus erythematosus α-Interferon
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