Targeting the PIAS1 SUMO ligase pathway to control inflammation

Protein sumoylation is a post-translational-modification event, in which small ubiquitin-like modifier (SUMO) is covalently attached to protein substrates by a three-step process. Sumoylation has been suggested to regulate multiple cellular processes, including inflammation. Inflammation is initiate...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2008-10, Vol.29 (10), p.505-509
Hauptverfasser:	Liu, Bin, Shuai, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Anti-Inflammatory Agents - pharmacology Drug Delivery Systems Humans Inflammation - drug therapy Inflammation - physiopathology NF-kappa B - metabolism Protein Inhibitors of Activated STAT - drug effects Protein Inhibitors of Activated STAT - metabolism STAT1 Transcription Factor - metabolism SUMO-1 Protein - drug effects SUMO-1 Protein - metabolism Ubiquitin-Protein Ligases - metabolism
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