Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury

Aims Thrombin activates protease-activated receptor 1 by proteolytic cleavage of the N-terminus. Although much research has focused on the activated receptor, little is known about the 41-amino acid N-terminal peptide (parstatin). We hypothesized that parstatin would protect the heart against ischae...

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Veröffentlicht in:	Cardiovascular research 2009-07, Vol.83 (2), p.325-334
Hauptverfasser:	Strande, Jennifer L., Widlansky, Michael E., Tsopanoglou, Nikos E., Su, Jidong, Wang, JingLi, Hsu, Anna, Routhu, Kasi V., Baker, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Cardioprotection Cardiotonic Agents - pharmacology Coronary Circulation - drug effects Cryptic peptide Disease Models, Animal Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Guanylate Cyclase - metabolism Heart Rate - drug effects Ischaemia KATP Channels - drug effects KATP Channels - metabolism Male Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocardium - pathology Nitric Oxide Synthase Type III - metabolism Original p38 Mitogen-Activated Protein Kinases - metabolism Peptide Fragments - pharmacology Potassium Channel Blockers - pharmacology Rats Rats, Sprague-Dawley Receptor, PAR-1 - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Reperfusion injury Signal Transduction - drug effects Soluble Guanylyl Cyclase Time Factors Vasodilation Vasodilation - drug effects Ventricular Function, Left - drug effects
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