IN VITRO CHARACTERIZATION OF A TARGETED, DYE-LOADED NANODEVICE FOR INTRAOPERATIVE TUMOR DELINEATION

Abstract OBJECTIVE To synthesize and complete in vitro characterization of a novel, tumor-targeted nanodevice for visible intraoperative delineation of brain tumors. METHODS The ability of dye-loaded polyacrylamide nanoparticles (NP) containing methylene blue, Coomassie blue, or indocyanine green to...

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Veröffentlicht in:	Neurosurgery 2009-05, Vol.64 (5), p.965-972
Hauptverfasser:	Orringer, Daniel A., Koo, Yong-Eun L., Chen, Thomas, Kim, Gwangseong, Hah, Hoe Jin, Xu, Hao, Wang, Shouyan, Keep, Richard, Philbert, Martin A., Kopelman, Raoul, Sagher, Oren
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - administration & dosage Acrylic Resins - metabolism Biological and medical sciences Brain cancer Cell Line, Tumor Colorimetry - methods Dose-Response Relationship, Drug Dyes Epitopes Fluorescent Dyes Glioma Glioma - metabolism Glioma - pathology Glioma - ultrastructure Humans Medical sciences Microscopy, Confocal Microscopy, Electron, Scanning - methods Nanoparticles - administration & dosage Neurosurgery Nucleolin Phosphoproteins - metabolism RNA-Binding Proteins - metabolism Subcellular Fractions - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors
Online-Zugang:	Volltext
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