Extrinsic Interactions Dominate Helical Propensity in Coupled Binding and Folding of the Lactose Repressor Protein Hinge Helix

A significant number of eukaryotic regulatory proteins are predicted to have disordered regions. Many of these proteins bind DNA, which may serve as a template for protein folding. Similar behavior is seen in the prokaryotic LacI/GalR family of proteins that couple hinge-helix folding with DNA bindi...

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Veröffentlicht in:	Biochemistry (Easton) 2006-05, Vol.45 (18), p.5896-5906
Hauptverfasser:	Zhan, Hongli, Swint-Kruse, Liskin, Matthews, Kathleen Shive
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - isolation & purification Bacterial Proteins - metabolism Base Sequence Circular Dichroism DNA Primers Lac Repressors Mutation Protein Binding Repressor Proteins - genetics Repressor Proteins - isolation & purification Repressor Proteins - metabolism
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