Myelin basic protein-reactive T cells persist in an inactive state in the bone marrow of Lewis rats that have recovered from autoimmune encephalomyelitis
Abstract Lewis rats immunized with guinea pig myelin basic protein residues 68–86 develop acute experimental autoimmune encephalomyelitis and recover. The predominant T cell receptor expressed by the encephalitogenic T cells is TCRBV8S2. They persist in bone marrow many weeks after recovery. CD3 is...
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| Veröffentlicht in: | Journal of neuroimmunology 2009-04, Vol.209 (1), p.26-32 |
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| creator | Kheradmand, Taba Wolf, Norbert A Swanborg, Robert H |
| description | Abstract Lewis rats immunized with guinea pig myelin basic protein residues 68–86 develop acute experimental autoimmune encephalomyelitis and recover. The predominant T cell receptor expressed by the encephalitogenic T cells is TCRBV8S2. They persist in bone marrow many weeks after recovery. CD3 is down-regulated, but > 90% express CD4. They fail to proliferate to GPMBP68–86 unless a nitric oxide synthase inhibitor is added to the cultures. Perhaps these are memory T cells that are maintained in a suppressed state in BM by a nitric oxide-dependent mechanism. |
| doi_str_mv | 10.1016/j.jneuroim.2009.01.018 |
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The predominant T cell receptor expressed by the encephalitogenic T cells is TCRBV8S2. They persist in bone marrow many weeks after recovery. CD3 is down-regulated, but > 90% express CD4. They fail to proliferate to GPMBP68–86 unless a nitric oxide synthase inhibitor is added to the cultures. Perhaps these are memory T cells that are maintained in a suppressed state in BM by a nitric oxide-dependent mechanism.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2009.01.018</identifier><identifier>PMID: 19211156</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Bone Marrow - drug effects ; Bone Marrow - immunology ; Bone Marrow - metabolism ; CD3 Complex - metabolism ; CD3 down-regulation ; CD4 Antigens - metabolism ; Cell Proliferation - drug effects ; Disease Models, Animal ; EAE ; Encephalomyelitis, Autoimmune, Experimental - chemically induced ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Encephalomyelitis, Autoimmune, Experimental - metabolism ; Enzyme Inhibitors - pharmacology ; Female ; Lymphocyte Activation - drug effects ; Lymphocyte Activation - physiology ; Memory T cells ; Myelin Basic Protein - immunology ; Myelin Basic Protein - metabolism ; Myelin Basic Protein - toxicity ; Neurology ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - metabolism ; Peptide Fragments - toxicity ; Rats ; Rats, Inbred Lew ; Receptors, Cell Surface - immunology ; Receptors, Cell Surface - metabolism ; Recovery of Function - immunology ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism</subject><ispartof>Journal of neuroimmunology, 2009-04, Vol.209 (1), p.26-32</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c502t-721710debc03ed96cfc64c101cb6ce3d4f6f0722675c6b8ab7f560cc5e2e4be63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2009.01.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19211156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kheradmand, Taba</creatorcontrib><creatorcontrib>Wolf, Norbert A</creatorcontrib><creatorcontrib>Swanborg, Robert H</creatorcontrib><title>Myelin basic protein-reactive T cells persist in an inactive state in the bone marrow of Lewis rats that have recovered from autoimmune encephalomyelitis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Lewis rats immunized with guinea pig myelin basic protein residues 68–86 develop acute experimental autoimmune encephalomyelitis and recover. The predominant T cell receptor expressed by the encephalitogenic T cells is TCRBV8S2. They persist in bone marrow many weeks after recovery. CD3 is down-regulated, but > 90% express CD4. They fail to proliferate to GPMBP68–86 unless a nitric oxide synthase inhibitor is added to the cultures. Perhaps these are memory T cells that are maintained in a suppressed state in BM by a nitric oxide-dependent mechanism.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Bone Marrow - drug effects</subject><subject>Bone Marrow - immunology</subject><subject>Bone Marrow - metabolism</subject><subject>CD3 Complex - metabolism</subject><subject>CD3 down-regulation</subject><subject>CD4 Antigens - metabolism</subject><subject>Cell Proliferation - drug effects</subject><subject>Disease Models, Animal</subject><subject>EAE</subject><subject>Encephalomyelitis, Autoimmune, Experimental - chemically induced</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - metabolism</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte Activation - physiology</subject><subject>Memory T cells</subject><subject>Myelin Basic Protein - immunology</subject><subject>Myelin Basic Protein - metabolism</subject><subject>Myelin Basic Protein - toxicity</subject><subject>Neurology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Peptide Fragments - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Receptors, Cell Surface - immunology</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Recovery of Function - immunology</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO1DAQjBCIHRZ-YeUTtwxtJ3aSywq0Wh7SIA4sEjfLcTqMQ2IH25nVfAp_i6MZnhcky5bc1dXdVZ1lVxS2FKh4MWwHi4t3ZtoygGYLNJ36QbahdcXyumT0YbZJQJ7zitUX2ZMQBgDKi7J5nF3QhlFKudhk398fcTSWtCoYTWbvIhqbe1Q6mgOSO6JxHAOZ0QcTIklIZdN9DoeoIq6fcY-kdRbJpLx398T1ZIf3JhCvYkhRFclepQSP2h3QY0d67yailpgmmJaUiFbjvFejm9aGoglPs0e9GgM-O7-X2afXt3c3b_Pdhzfvbl7tcs2BxbxitKLQYauhwK4Rutei1Ekj3QqNRVf2ooeKMVFxLdpatVXPBWjNkWHZoigus-sT77y0E3YabfRqlLM3aZajdMrIvyPW7OUXd5BMNA2vIRE8PxN4923BEOVkwiqbsuiWIBlwVhZNlYDiBNTeheCx_1WEglxdlYP86apcXZVA06lT4tWfLf5OO9uYAC9PAExCHQx6GbRZFe1MUjzKzpn_17j-h0KnvTBajV_xiGFwi7fJBkllYBLkx3W31tWCBgBY8bn4AXNl0fY</recordid><startdate>20090430</startdate><enddate>20090430</enddate><creator>Kheradmand, Taba</creator><creator>Wolf, Norbert A</creator><creator>Swanborg, Robert H</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20090430</creationdate><title>Myelin basic protein-reactive T cells persist in an inactive state in the bone marrow of Lewis rats that have recovered from autoimmune encephalomyelitis</title><author>Kheradmand, Taba ; Wolf, Norbert A ; Swanborg, Robert H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-721710debc03ed96cfc64c101cb6ce3d4f6f0722675c6b8ab7f560cc5e2e4be63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Bone Marrow - drug effects</topic><topic>Bone Marrow - immunology</topic><topic>Bone Marrow - metabolism</topic><topic>CD3 Complex - metabolism</topic><topic>CD3 down-regulation</topic><topic>CD4 Antigens - metabolism</topic><topic>Cell Proliferation - drug effects</topic><topic>Disease Models, Animal</topic><topic>EAE</topic><topic>Encephalomyelitis, Autoimmune, Experimental - chemically induced</topic><topic>Encephalomyelitis, Autoimmune, Experimental - immunology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - metabolism</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Female</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocyte Activation - physiology</topic><topic>Memory T cells</topic><topic>Myelin Basic Protein - immunology</topic><topic>Myelin Basic Protein - metabolism</topic><topic>Myelin Basic Protein - toxicity</topic><topic>Neurology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Peptide Fragments - toxicity</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Receptors, Cell Surface - immunology</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Recovery of Function - immunology</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kheradmand, Taba</creatorcontrib><creatorcontrib>Wolf, Norbert A</creatorcontrib><creatorcontrib>Swanborg, Robert H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kheradmand, Taba</au><au>Wolf, Norbert A</au><au>Swanborg, Robert H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myelin basic protein-reactive T cells persist in an inactive state in the bone marrow of Lewis rats that have recovered from autoimmune encephalomyelitis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2009-04-30</date><risdate>2009</risdate><volume>209</volume><issue>1</issue><spage>26</spage><epage>32</epage><pages>26-32</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Lewis rats immunized with guinea pig myelin basic protein residues 68–86 develop acute experimental autoimmune encephalomyelitis and recover. The predominant T cell receptor expressed by the encephalitogenic T cells is TCRBV8S2. They persist in bone marrow many weeks after recovery. CD3 is down-regulated, but > 90% express CD4. They fail to proliferate to GPMBP68–86 unless a nitric oxide synthase inhibitor is added to the cultures. Perhaps these are memory T cells that are maintained in a suppressed state in BM by a nitric oxide-dependent mechanism.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>19211156</pmid><doi>10.1016/j.jneuroim.2009.01.018</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Animals Bone Marrow - drug effects Bone Marrow - immunology Bone Marrow - metabolism CD3 Complex - metabolism CD3 down-regulation CD4 Antigens - metabolism Cell Proliferation - drug effects Disease Models, Animal EAE Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Enzyme Inhibitors - pharmacology Female Lymphocyte Activation - drug effects Lymphocyte Activation - physiology Memory T cells Myelin Basic Protein - immunology Myelin Basic Protein - metabolism Myelin Basic Protein - toxicity Neurology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Peptide Fragments - toxicity Rats Rats, Inbred Lew Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Recovery of Function - immunology T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism |
| title | Myelin basic protein-reactive T cells persist in an inactive state in the bone marrow of Lewis rats that have recovered from autoimmune encephalomyelitis |
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