NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644

We have previously shown that P7 rat pups injected with the N-methyl- d-aspartate receptor (NMDAR) blocker MK801 displayed robust apoptotic injury within hours after injection. Further studies from our lab suggest that loss of calcium cannot be compensated for when vulnerable neurons lack calcium bu...

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Veröffentlicht in:	Neuroscience letters 2009-02, Vol.450 (3), p.292-295
Hauptverfasser:	Turner, Christopher P., DeBenedetto, Danielle, Liu, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Anesthetics Animals Animals, Newborn Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Brain - drug effects Brain - pathology Brain - physiopathology Brain Damage, Chronic - chemically induced Brain Damage, Chronic - pathology Brain Damage, Chronic - physiopathology Calcium Channel Agonists - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Disease Models, Animal Dizocilpine Dizocilpine Maleate - toxicity Excitatory Amino Acid Antagonists - toxicity Fundamental and applied biological sciences. Psychology MK801 Neostriatum - drug effects Neostriatum - pathology Neostriatum - physiopathology Nerve Degeneration - chemically induced Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neurons - drug effects Neurons - metabolism Neurons - pathology Postnatal Rat Rats Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Set point hypothesis Somatosensory Cortex - drug effects Somatosensory Cortex - pathology Somatosensory Cortex - physiopathology Vertebrates: nervous system and sense organs
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