DC activated via dectin-1 convert Treg into IL-17 producers

Th cells producing IL-17 play a pro-inflammatory role at mucosal surfaces. Treg at the same sites dampen inflammation and prevent immunopathology. Th cells producing IL-17 (Th17) and Treg are thought to be distinct populations defined by expression of the transcription factors ROR-γt and Foxp3, resp...

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Veröffentlicht in:	European journal of immunology 2008-12, Vol.38 (12), p.3274-3281
Hauptverfasser:	Osorio, Fabiola, LeibundGut-Landmann, Salomé, Lochner, Matthias, Lahl, Katharina, Sparwasser, Tim, Eberl, Gérard, Reis e Sousa, Caetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - immunology Dectin‐1 Dendritic Cells - drug effects Dendritic Cells - immunology Forkhead Transcription Factors - immunology Highlights Interleukin-17 - biosynthesis Interleukin-17 - immunology Interleukin-2 Receptor alpha Subunit - immunology Interleukin-23 - deficiency Interleukin-23 - genetics Interleukin-23 - metabolism Lectins, C-Type Membrane Proteins - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - pharmacology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th17 Treg
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