Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining lymph nodes (TDLNs), where it can potently activate Foxp3+ regulatory T cells (Tregs). We now show that IDO functions as a molecular switch in TDLNs, maintaining...

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Veröffentlicht in:	Blood 2009-06, Vol.113 (24), p.6102-6111
Hauptverfasser:	Sharma, Madhav D., Hou, De-Yan, Liu, Yanjun, Koni, Pandelakis A., Metz, Richard, Chandler, Phillip, Mellor, Andrew L., He, Yukai, Munn, David H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Biological and medical sciences Blotting, Western Cancer Vaccines - therapeutic use Chickens Dendritic Cells - immunology Forkhead Transcription Factors - metabolism Hematologic and hematopoietic diseases Immunobiology Immunophenotyping Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology Interleukin-17 - metabolism Interleukin-6 - metabolism Lymph Nodes - enzymology Lymph Nodes - immunology Lymphocyte Activation Medical sciences Melanoma, Experimental - enzymology Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice Mice, Knockout Mice, Transgenic Ovalbumin - physiology Receptors, Antigen, T-Cell - physiology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - pathology T-Lymphocytes, Regulatory - immunology
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