In search of nonribosomal nucleolar protein function and regulation

The life of the nucleolus has proven to be more colorful and multifaceted than had been envisioned a decade ago. A large number of proteins found in this subnuclear compartment have no identifiable tie either to the ribosome biosynthetic pathway or to the other newly established activities occurring...

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Veröffentlicht in:	The Journal of cell biology 2009-03, Vol.184 (6), p.771-776
Hauptverfasser:	Pederson, Thoru, Tsai, Robert Y.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cell Cycle Cell Cycle Proteins - metabolism Cell nucleolus Cell Nucleolus - enzymology Cell Nucleolus - metabolism Cells Gene expression regulation HeLa cells Humans Mini-Review Mitosis Nuclear proteins Nuclear Proteins - metabolism Phosphoric Monoester Hydrolases - metabolism Protein Transport Proteins Reviews Ribonucleic acid Ribosomal Proteins - metabolism Ribosomes RNA RNA Precursors - metabolism RNA, Ribosomal - metabolism Stem cells
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Beschreibung
Zusammenfassung:	The life of the nucleolus has proven to be more colorful and multifaceted than had been envisioned a decade ago. A large number of proteins found in this subnuclear compartment have no identifiable tie either to the ribosome biosynthetic pathway or to the other newly established activities occurring within the nucleolus. The questions of how and why these proteins end up in this subnuclear compartment remain unanswered and are the focus of intense current interest. This review discusses our thoughts on the discovery of nonribosomal proteins in the nucleolus.
ISSN:	0021-9525 1540-8140
DOI:	10.1083/jcb.200812014