Life and death by death receptors

Death receptors are members of the tumor necrosis factor receptor superfamily characterized by a cytoplasmic region known as the "death domain" that enables the receptors to initiate cytotoxic signals when engaged by cognate ligands. Binding to the ligand results in receptor aggregation an...

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Veröffentlicht in:	The FASEB journal 2009-06, Vol.23 (6), p.1625-1637
Hauptverfasser:	Guicciardi, Maria Eugenia, Gores, Gregory J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Bcl‐2 family caspases Fas Ligand Protein - genetics Fas Ligand Protein - metabolism fas Receptor - genetics fas Receptor - metabolism Fas/CD95/APO1 Humans MAP kinases Receptors, Death Domain - genetics Receptors, Death Domain - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - metabolism Reviews Signal Transduction - physiology TNF TRAIL Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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