Immune dysregulation in severe influenza

Among previously healthy children with severe influenza, the mechanisms leading to increased pathology are not understood. We hypothesized that children with severe influenza would have high levels of circulating cytokines. To examine this, we recruited patients with severe influenza and examined pl...

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Veröffentlicht in:	Journal of leukocyte biology 2009-06, Vol.85 (6), p.1036-1043
Hauptverfasser:	Heltzer, Meredith L., Coffin, Susan E., Maurer, Kelly, Bagashev, Asen, Zhang, Zhe, Orange, Jordan S., Sullivan, Kathleen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Child, Preschool Children Cytokines Cytokines - blood Female Flow Cytometry g-Interferon Gene Expression Regulation Host Defense and Pathophysiology Humans IFN IL‐6 Immune System Diseases - complications Immune System Diseases - immunology Immune System Diseases - physiopathology Infant Influenza Influenza, Human - complications Influenza, Human - genetics Influenza, Human - immunology Influenza, Human - physiopathology Inoculum Interferon Interferon Regulatory Factors - metabolism Interleukin 12 Interleukin 6 IRF4 Killer Cells, Natural - immunology Killer Cells, Natural - virology Leukocytes Leukocytes, Mononuclear - virology Male Multiplicity of infection Natural Cytotoxicity Triggering Receptor 1 - immunology Natural killer cells NK cells NKp46 Peripheral blood Plasma levels Replication Respiratory syncytial virus TLR Toll-Like Receptors - metabolism Tumor necrosis factor-a
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