Selective desensitization of the 5‐HT4 receptor‐mediated response in pig atrium but not in stomach

Background and purpose: The time dependency of the effect of 5‐HT4 receptor agonists depends on many specific regulatory mechanisms, which vary between tissues. This has important implications with regard to the effects of endogenous 5‐HT, as well as to the clinical use of 5‐HT4 receptor agonists,...

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Veröffentlicht in:	British journal of pharmacology 2009-01, Vol.156 (2), p.362-376
Hauptverfasser:	De Maeyer, JH, Schuurkes, JAJ, Lefebvre, RA
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT4 receptor Animals Atrial Function, Left - drug effects Benzofurans - adverse effects Benzofurans - pharmacology Biological and medical sciences desensitization Female In Vitro Techniques left atrium M0003 Medical sciences Models, Biological Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - physiology Myocardial Contraction - drug effects Organ Specificity Pharmacology. Drug treatments proximal stomach prucalopride Receptors, Serotonin, 5-HT4 - physiology Research Paper Serotonin 5-HT4 Receptor Agonists Serotonin 5-HT4 Receptor Antagonists Stomach - drug effects Stomach - innervation Stomach - physiology Swine Synaptic Transmission Tachyphylaxis
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