Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

DNA/cationic lipid (lipoplexes), DNA/cationic polymer (polyplexes) and DNA/cationic polymer/cationic lipid (lipopolyplexes) electrostatic complexes are proposed as non‐viral nucleic acids delivery systems. These DNA‐nanoparticles are taken up by the cells through endocytosis processes, but the low c...

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Veröffentlicht in:	British journal of pharmacology 2009-05, Vol.157 (2), p.166-178
Hauptverfasser:	Midoux, Patrick, Pichon, Chantal, Yaouanc, Jean‐Jacques, Jaffrès, Paul‐Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	cationic lipids cationic polymers Chemical Sciences Drug Carriers endosome escape fusogenic peptides gene transfer Genetic Vectors Histidine - analysis Imidazoles - analysis imidazolinium and imidazolium Lipids - chemistry non‐viral vectors Nucleic Acids - administration & dosage Organic chemistry Peptides - chemistry pH‐sensitive membrane fusion pH‐sensitive membrane permeation Polymers - chemistry SiRNA Themed Section: Reviews Transfection
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