Structure of the Inhibitor W7 Bound to the Regulatory Domain of Cardiac Troponin C

The calmodulin antagonist W7 binds to troponin C in the presence of Ca2+ and inhibits striated muscle contraction. This study integrates multiple data into the structure of the regulatory domain of human cardiac troponin C (cNTnC) bound to Ca2+ and W7. The protein−W7 interface is defined through a t...

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Veröffentlicht in:	Biochemistry (Easton) 2009-06, Vol.48 (24), p.5541-5552
Hauptverfasser:	Hoffman, Ryan M. B, Sykes, Brian D
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Humans Models, Molecular Protein Conformation Protein Structure, Tertiary Structure-Activity Relationship Sulfonamides - chemistry Sulfonamides - metabolism Troponin C - chemistry Troponin C - metabolism
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