Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina

We tested whether horizontal cells (HCs) provide feedback that regulates the Ca 2+ current ( I Ca ) of rods in salamander and mouse retinas. In both species, hyperpolarizing HCs by puffing a glutamate antagonist, 6,7-dinitro-quinoxaline-2,3-dione (DNQX), onto HC processes caused a negative shift in...

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Veröffentlicht in:	The Journal of physiology 2009-05, Vol.587 (10), p.2353-2364
Hauptverfasser:	Babai, Norbert, Thoreson, Wallace B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambystoma Aniline Compounds - metabolism Animals Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Caudata Cytoplasm - metabolism Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Feedback - drug effects Feedback - physiology HEPES - pharmacology Kainic Acid - pharmacology Membrane Potentials - drug effects Membrane Potentials - physiology Mice Mice, Inbred C57BL Microscopy, Confocal Neuroscience Photic Stimulation Potassium - pharmacology Quinoxalines - pharmacology Retina - drug effects Retina - physiology Retinal Horizontal Cells - drug effects Retinal Horizontal Cells - physiology Retinal Rod Photoreceptor Cells - drug effects Retinal Rod Photoreceptor Cells - physiology Xanthenes - metabolism
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