Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain: Clinical Implications

CONTEXT Modafinil, a wake-promoting drug used to treat narcolepsy, is increasingly being used as a cognitive enhancer. Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting dopamine transporters, recent preclinical studies suggest otherwise. OBJECT...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2009-03, Vol.301 (11), p.1148-1154
Hauptverfasser:	Volkow, Nora D, Fowler, Joanna S, Logan, Jean, Alexoff, David, Zhu, Wei, Telang, Frank, Wang, Gene-Jack, Jayne, Millard, Hooker, Jacob M, Wong, Christopher, Hubbard, Barbara, Carter, Pauline, Warner, Donald, King, Payton, Shea, Colleen, Xu, Youwen, Muench, Lisa, Apelskog-Torres, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Benzhydryl Compounds - administration & dosage Benzhydryl Compounds - pharmacology Biological and medical sciences Brain Brain - diagnostic imaging Brain - drug effects Brain - metabolism Carbon Radioisotopes Caudate Nucleus - metabolism Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacology Clinical outcomes Cocaine Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors General aspects Humans Male Medical sciences Medical treatment Middle Aged Neuropharmacology Nucleus Accumbens - metabolism Pharmacology. Drug treatments Pilot Projects Positron-Emission Tomography Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Putamen - metabolism Raclopride Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - metabolism Stimulants Substance-Related Disorders Young Adult
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