Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?
Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of th...
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| Veröffentlicht in: | Schizophrenia bulletin 2009-07, Vol.35 (4), p.748-759 |
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| creator | Calzavara, Mariana Bendlin Medrano, Wladimir Agostini Levin, Raquel Kameda, Sonia Regina Andersen, Monica Levy Tufik, Sergio Silva, Regina Helena Frussa-Filho, Roberto Abílio, Vanessa Costhek |
| description | Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). The effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. The repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia. |
| doi_str_mv | 10.1093/schbul/sbn006 |
| format | Article |
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A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). The effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. The repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/sbn006</identifier><identifier>PMID: 18281713</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult and adolescent clinical studies ; Amphetamine - pharmacology ; Animals ; Antipsychotic Agents - pharmacology ; Arterial hypertension. Arterial hypotension ; Behavior, Animal - drug effects ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Conditioning (Psychology) - drug effects ; Conditioning (Psychology) - physiology ; Disease Models, Animal ; Dopamine Antagonists - pharmacology ; Electroshock ; Emotions - drug effects ; Fear - drug effects ; Fear - physiology ; Freezing Reaction, Cataleptic - drug effects ; Inhibition (Psychology) ; Male ; Medical sciences ; Memory - drug effects ; Neuropharmacology ; Pain Threshold - drug effects ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Psychoses ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rats, Wistar ; Regular ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - drug therapy ; Schizophrenic Psychology ; Sleep Deprivation ; Vocalization, Animal - drug effects</subject><ispartof>Schizophrenia bulletin, 2009-07, Vol.35 (4), p.748-759</ispartof><rights>The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org. 2009</rights><rights>2009 INIST-CNRS</rights><rights>The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-86a2181c7054938f45f4b17879b62219b24c11f9341a19d1c9953935ec841ba63</citedby><cites>FETCH-LOGICAL-c541t-86a2181c7054938f45f4b17879b62219b24c11f9341a19d1c9953935ec841ba63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696367/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696367/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1584,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21640385$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18281713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calzavara, Mariana Bendlin</creatorcontrib><creatorcontrib>Medrano, Wladimir Agostini</creatorcontrib><creatorcontrib>Levin, Raquel</creatorcontrib><creatorcontrib>Kameda, Sonia Regina</creatorcontrib><creatorcontrib>Andersen, Monica Levy</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><creatorcontrib>Silva, Regina Helena</creatorcontrib><creatorcontrib>Frussa-Filho, Roberto</creatorcontrib><creatorcontrib>Abílio, Vanessa Costhek</creatorcontrib><title>Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). The effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. The repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia.</description><subject>Adult and adolescent clinical studies</subject><subject>Amphetamine - pharmacology</subject><subject>Animals</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>Conditioning (Psychology) - physiology</subject><subject>Disease Models, Animal</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Electroshock</subject><subject>Emotions - drug effects</subject><subject>Fear - drug effects</subject><subject>Fear - physiology</subject><subject>Freezing Reaction, Cataleptic - drug effects</subject><subject>Inhibition (Psychology)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Neuropharmacology</subject><subject>Pain Threshold - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Psychoses</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Rats, Wistar</subject><subject>Regular</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenic Psychology</subject><subject>Sleep Deprivation</subject><subject>Vocalization, Animal - drug effects</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhyBVZSCAuoZ74IzYH0GrbUqQCVQvnyPE6u66ydrCdFctP49fhVVbl48Jp5JnH77wavUXxFPBrwJKcRL1ux_4ktg5jfq-YQU1ZCTWG-8UMM8HLmgM9Kh7FeIsxUMmrh8URiEpADWRW_PxkxuB7MySr0WkYVxFdm60JCaW1QQvvkvmeRtWjc6PC_r20yXpn3Qqdms5qm9BVMNFkbonaHboZ8hfljB9jv0MXuyFLGRft1qBrleIbNEdXPneSzZpzZze5fPRL0yPfobON34vn1mFx1vbaxLhfZx260Wv7ww_rYJxV7x4XDzrVR_PkUI-Lr-dnXxYX5eXn9x8W88tSMwqpFFxVIEDXmFFJREdZR1uoRS1bXlUg24pqgE4SCgrkErSUjEjCjBYUWsXJcfF20h3GdmOWOpsPqm-GkM2HXeOVbf6eOLtuVn7bVFxywuss8PIgEPy30cTUbGzUpu-nOzUZEQIIzuDzf8BbP4Z8j9hUFWGM1ExkqJwgHXyMwXR3TgA3-0g0UySaKRKZf_an_d_0IQMZeHEAVNSq74Jy2sY7rgJOMREsc68mzo_Df3b-AoEm0tM</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Calzavara, Mariana Bendlin</creator><creator>Medrano, Wladimir Agostini</creator><creator>Levin, Raquel</creator><creator>Kameda, Sonia Regina</creator><creator>Andersen, Monica Levy</creator><creator>Tufik, Sergio</creator><creator>Silva, Regina Helena</creator><creator>Frussa-Filho, Roberto</creator><creator>Abílio, Vanessa Costhek</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?</title><author>Calzavara, Mariana Bendlin ; Medrano, Wladimir Agostini ; Levin, Raquel ; Kameda, Sonia Regina ; Andersen, Monica Levy ; Tufik, Sergio ; Silva, Regina Helena ; Frussa-Filho, Roberto ; Abílio, Vanessa Costhek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-86a2181c7054938f45f4b17879b62219b24c11f9341a19d1c9953935ec841ba63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Amphetamine - pharmacology</topic><topic>Animals</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Conditioning (Psychology) - drug effects</topic><topic>Conditioning (Psychology) - physiology</topic><topic>Disease Models, Animal</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Electroshock</topic><topic>Emotions - drug effects</topic><topic>Fear - drug effects</topic><topic>Fear - physiology</topic><topic>Freezing Reaction, Cataleptic - drug effects</topic><topic>Inhibition (Psychology)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Neuropharmacology</topic><topic>Pain Threshold - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Psychoses</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Rats, Wistar</topic><topic>Regular</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenic Psychology</topic><topic>Sleep Deprivation</topic><topic>Vocalization, Animal - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calzavara, Mariana Bendlin</creatorcontrib><creatorcontrib>Medrano, Wladimir Agostini</creatorcontrib><creatorcontrib>Levin, Raquel</creatorcontrib><creatorcontrib>Kameda, Sonia Regina</creatorcontrib><creatorcontrib>Andersen, Monica Levy</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><creatorcontrib>Silva, Regina Helena</creatorcontrib><creatorcontrib>Frussa-Filho, Roberto</creatorcontrib><creatorcontrib>Abílio, Vanessa Costhek</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calzavara, Mariana Bendlin</au><au>Medrano, Wladimir Agostini</au><au>Levin, Raquel</au><au>Kameda, Sonia Regina</au><au>Andersen, Monica Levy</au><au>Tufik, Sergio</au><au>Silva, Regina Helena</au><au>Frussa-Filho, Roberto</au><au>Abílio, Vanessa Costhek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>35</volume><issue>4</issue><spage>748</spage><epage>759</epage><pages>748-759</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). The effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. The repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>18281713</pmid><doi>10.1093/schbul/sbn006</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult and adolescent clinical studies Amphetamine - pharmacology Animals Antipsychotic Agents - pharmacology Arterial hypertension. Arterial hypotension Behavior, Animal - drug effects Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Disease Models, Animal Dopamine Antagonists - pharmacology Electroshock Emotions - drug effects Fear - drug effects Fear - physiology Freezing Reaction, Cataleptic - drug effects Inhibition (Psychology) Male Medical sciences Memory - drug effects Neuropharmacology Pain Threshold - drug effects Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Rats Rats, Inbred SHR Rats, Inbred WKY Rats, Wistar Regular Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Schizophrenic Psychology Sleep Deprivation Vocalization, Animal - drug effects |
| title | Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
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