Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance
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| Veröffentlicht in: | Advances in enzyme regulation 2007, Vol.47 (1), p.64-103 |
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| container_title | Advances in enzyme regulation |
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| creator | McCubrey, James A Steelman, Linda S Franklin, Richard A Abrams, Steven L Chappell, William H Wong, Ellis W T Lehmann, Brian D Terrian, David M Basecke, Jorg Stivala, Franca Libra, Massimo Evangelisti, Camilla Martelli, Alberto M |
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| doi_str_mv | 10.1016/j.advenzreg.2006.12.013 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Advances in enzyme regulation, 2007, Vol.47 (1), p.64-103 |
| issn | 0065-2571 1873-2437 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Drug Delivery Systems - methods Drug Resistance, Neoplasm - physiology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - biosynthesis Extracellular Signal-Regulated MAP Kinases - genetics Hematologic Neoplasms - drug therapy Hematologic Neoplasms - enzymology Hematologic Neoplasms - metabolism Mice Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - biosynthesis Mitogen-Activated Protein Kinase Kinases - genetics Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - biosynthesis Phosphatidylinositol 3-Kinases - genetics Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - genetics raf Kinases - antagonists & inhibitors raf Kinases - biosynthesis raf Kinases - genetics raf Kinases - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics |
| title | Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance |
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