Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance

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Veröffentlicht in:	Advances in enzyme regulation 2007, Vol.47 (1), p.64-103
Hauptverfasser:	McCubrey, James A, Steelman, Linda S, Franklin, Richard A, Abrams, Steven L, Chappell, William H, Wong, Ellis W T, Lehmann, Brian D, Terrian, David M, Basecke, Jorg, Stivala, Franca, Libra, Massimo, Evangelisti, Camilla, Martelli, Alberto M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Drug Delivery Systems - methods Drug Resistance, Neoplasm - physiology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - biosynthesis Extracellular Signal-Regulated MAP Kinases - genetics Hematologic Neoplasms - drug therapy Hematologic Neoplasms - enzymology Hematologic Neoplasms - metabolism Mice Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - biosynthesis Mitogen-Activated Protein Kinase Kinases - genetics Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - biosynthesis Phosphatidylinositol 3-Kinases - genetics Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - genetics raf Kinases - antagonists & inhibitors raf Kinases - biosynthesis raf Kinases - genetics raf Kinases - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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ISSN:	0065-2571 1873-2437
DOI:	10.1016/j.advenzreg.2006.12.013